CAJ | 학술논문

目的：程序性死亡分子-1（programmed death-1，PD-1）是近年来发现的属于B7/CD28家族的重要协同刺激分子，与其配体（programmed death -1 ligand，PD-L）结合后在调节T淋巴细胞的活化、分化及增殖功能方面起着重要作用。在慢性HBV感染不同阶段，PD-1表达水平存在差异，且与肝脏炎症程度、ALT及病毒载量等密切相关。通过不同途径阻断PD-1/PD-L1通路可以使耗竭的T淋巴细胞功能得到改善，提示可能是未来抗病毒治疗的方向之一。
목적：정서성사망분자-1（programmed death-1，PD-1）시근년래발현적속우B7/CD28가족적중요협동자격분자，여기배체（programmed death -1 ligand，PD-L）결합후재조절T림파세포적활화、분화급증식공능방면기착중요작용。재만성HBV감염불동계단，PD-1표체수평존재차이，차여간장염증정도、ALT급병독재량등밀절상관。통과불동도경조단PD-1/PD-L1통로가이사모갈적T림파세포공능득도개선，제시가능시미래항병독치료적방향지일。
Programmed death-1(PD-1) is an important coordinated stimulus molecule belonging to the B7/CD28 family. When it combines with its ligand programmed death ligand (PD-L),can regulate the activation,differentiation and multiplication of T lymphocytes. PD-1 expression in different stages of chronic HBV infection varies ,and is closely related to the degree of liver inflammation,ALT levels and viral loads. Through different ways to block the PD-1/PD-L1 pathway can improve the function of T lymphocytes,and it might be one of the direction for antiretroviral treatment in the future.