CAJ | 학술논문

药物的肝脏毒性是欧美国家导致急性肝衰竭的重要原因。Kaplowitz提出的以特异性“上游”事件和非特异性“下游”事件为基础的DILI（Drug induced liver injury，DILI）发病机制，为进一步开展DILI机制的研究提供了明确的方向。目前已知，DILI的发生机制复杂，涉及药物代谢、线粒体功能损伤、免疫反应、信号转导、遗传和环境等多个方面。DILI的发生和进展可能是多重因素综合作用的结果。
약물적간장독성시구미국가도치급성간쇠갈적중요원인。Kaplowitz제출적이특이성“상유”사건화비특이성“하유”사건위기출적DILI（Drug induced liver injury，DILI）발병궤제，위진일보개전DILI궤제적연구제공료명학적방향。목전이지，DILI적발생궤제복잡，섭급약물대사、선립체공능손상、면역반응、신호전도、유전화배경등다개방면。DILI적발생화진전가능시다중인소종합작용적결과。
DILI is the most important cause of acute liver failure in the U.S. The emerging concept of drug -specific “upstream” events that cause initial hepatocyte injury and less specific“downstream”events described by Kaplowitz,which provides clear direction for further DILI mechanism research. Currently,it’s well-know that the mechanism of DILI is complex,involving drug metabolism,mitochondrial dysfunction,immune response,signal transduction,genetic and environmental et al. Progression of DILI may be the result of the combined effects of multiple factors.