CAJ | 학술논문

目的：探讨人微小病毒B19肝炎患者的临床特征。方法对17例感染人微小病毒B19患者的病历资料进行回顾性分析，总结肝损害的特点和临床特征。结果17例人微小病毒B19肝炎患者均有发热（100%），有全身乏力14例（82.4%）、关节、肌肉痛9例（52.9%）、咽痛6例（35.3%）、食欲减退11例（64.7%）、皮疹5例（29.4%）、脾肿大12例（70.6%），肝肿大7例（41.2%）、淋巴结肿大3例（17.6%）、黄疸5例（29.4%）；除血ALT和AST升高外，伴有羟丁酸脱氢酶、乳酸脱氢酶、腺苷脱氨酶升高和淋巴细胞百分比升高；起病急，临床表现复杂，但多呈急性自限性过程，肝功能恢复较快，预后较好。结论对不明原因肝损害同时伴有上述特征者，除常规筛查常见的嗜肝病毒外，及时检测血清抗人微小病毒B19抗体IgM，能帮助明确一部分患者的病因。
목적：탐토인미소병독B19간염환자적림상특정。방법대17례감염인미소병독B19환자적병력자료진행회고성분석，총결간손해적특점화림상특정。결과17례인미소병독B19간염환자균유발열（100%），유전신핍력14례（82.4%）、관절、기육통9례（52.9%）、인통6례（35.3%）、식욕감퇴11례（64.7%）、피진5례（29.4%）、비종대12례（70.6%），간종대7례（41.2%）、림파결종대3례（17.6%）、황달5례（29.4%）；제혈ALT화AST승고외，반유간정산탈경매、유산탈경매、선감탈안매승고화림파세포백분비승고；기병급，림상표현복잡，단다정급성자한성과정，간공능회복교쾌，예후교호。결론대불명원인간손해동시반유상술특정자，제상규사사상견적기간병독외，급시검측혈청항인미소병독B19항체IgM，능방조명학일부분환자적병인。
Objective To summarize the clinical characteristics of patients with human parvovirus B19 (HPV) infection. Methods The clinical materials in 17 patients with human parvovirus B19 infection was retrospectively summarized,and the clinical features,laboratory findings and radiologic imaging were analyzed. Results The predominant symptoms and signs of patients in this series were:fever (100.0%),general fatigue (82.4%),arthralgia/myalgia (52.9%),pharyngalgia(17.4%),anorexia(64.7%),rash(17.3%),splenomegaly (70.6%), hepatomegaly (41.2%),lymphadenectasis (17.6%) and jaundice (17.3%);The laboratory findings showed elevated serum alanine aminotransferase and aspartate transferase,lactate dehydrogenase,hydroxybutyrate dehydrogenase and adenosine deaminase levels,and higher lymphocyte counts;Hepatic injury caused by HPV B19 infection had features of acute onset and complicated clinical manifestations,but with a self-limited illness course. The recovery of liver function was rapid and the prognosis was relatively good. Conclusion The patients who have unexplained hepatic injury should have a prompt detection of serum anti-HPV B19 IgM,especially in those with negative serum hepatitis A,B,C and E virus markers.