CAJ | 학술논문

目的：对比研究不同剂量心脏停跳液在室间隔缺损患儿中的心肌保护效果。方法选取45例室间隔缺损患儿，随机分为不同剂量组：1/3剂量组（5 mL/kg）、1/2剂量组（7.5 mL/kg）、全剂量组（15 mL/kg），每组各15例。观察3组患儿的心跳复苏情况、心肌阻断时间、体外循环（CPB）时间、心肌酶学变化、血管活性药物应用及ICU停留时间。结果3组患儿均顺利复跳、停机，全部存活出院。3组病例心肌阻断时间、体外循环时间、心肌酶学、血管活性药物应用及ICU停留时间无统计学差异（ P＞0.05）。结论在室间隔缺损的患儿中应用不同剂量的灌注方案是安全可行的。
목적：대비연구불동제량심장정도액재실간격결손환인중적심기보호효과。방법선취45례실간격결손환인，수궤분위불동제량조：1/3제량조（5 mL/kg）、1/2제량조（7.5 mL/kg）、전제량조（15 mL/kg），매조각15례。관찰3조환인적심도복소정황、심기조단시간、체외순배（CPB）시간、심기매학변화、혈관활성약물응용급ICU정류시간。결과3조환인균순리복도、정궤，전부존활출원。3조병례심기조단시간、체외순배시간、심기매학、혈관활성약물응용급ICU정류시간무통계학차이（ P＞0.05）。결론재실간격결손적환인중응용불동제량적관주방안시안전가행적。
Objective To comparatively study the myocardial protective effects of different dose of cold crystalloid hyperkalemic cardioplegia in infants with ventricular septal defect ( VSD) undergoing open heart surgery.Methods Forty-five infant patients ( weight≤10 kg) with VSD were randomly divided into three groups (15 cases of each group):1/3 dosage group (5 mL/kg), 1/2 dosage group (7.5 mL/kg), and total dosage group (15 mL/kg).Plasma levels of CK, CK-MB, LDH, cTnI, ET-1 were measured before aortic cross-clamp and after wean-off cardiopulmonary bypass (CPB).The ratio of spontaneous cardiac rhythm recovery, dose of inotropic drugs application, CPB time, aortic cross-clamp time, mechanical ventilation support time and ICU stay-time were recorded.Results All the patients were healed and dis-charged after heart re-beat.The ratio of spontaneous cardiac rhythm recovery, CPB time, aortic cross-clamp time, mechanical ventilation support time and ICU stay-time had no statistic differ-ence between three groups.Conclusion It is reliable and effective to use different dose of cold crystalloid hyperkalemic cardioplegia in infants with VSD undergoing open heart surgery.