CAJ | 학술논문

目的：探讨不同年龄组2型糖尿病患者非酒精性脂肪肝与颈动脉内膜厚度的关系。方法收集211例2型糖尿病患者，其中合并非酒精性脂肪肝（nonalcoholic fatty liver disease，NAFLD）113例，不伴NAFLD98例，并按年龄分组，对各组间临床及生化资料进行比较。结果2型糖尿病伴NAFLD颈动脉内膜厚度明显增加（P＜0.05），经Logistic分析发现45岁以下及60岁以上2型糖尿病患者NAFLD与颈动脉内膜厚度无关（ P＞0.05），45岁至60岁2型糖尿病患者NAFLD与颈动脉内膜厚度有显著相关（ P＜0.05）。结论 NAFLD是2型糖尿病患者颈动脉内膜增厚的主要危险因素之一，对于45岁以上2型糖尿病合并NAFLD患者需积极防控动脉粥样硬化的发生，65岁以上2型糖尿病患者不管是否伴NAFLD均需抗动脉粥样硬化治疗。
목적：탐토불동년령조2형당뇨병환자비주정성지방간여경동맥내막후도적관계。방법수집211례2형당뇨병환자，기중합병비주정성지방간（nonalcoholic fatty liver disease，NAFLD）113례，불반NAFLD98례，병안년령분조，대각조간림상급생화자료진행비교。결과2형당뇨병반NAFLD경동맥내막후도명현증가（P＜0.05），경Logistic분석발현45세이하급60세이상2형당뇨병환자NAFLD여경동맥내막후도무관（ P＞0.05），45세지60세2형당뇨병환자NAFLD여경동맥내막후도유현저상관（ P＜0.05）。결론 NAFLD시2형당뇨병환자경동맥내막증후적주요위험인소지일，대우45세이상2형당뇨병합병NAFLD환자수적겁방공동맥죽양경화적발생，65세이상2형당뇨병환자불관시부반NAFLD균수항동맥죽양경화치료。
Objective To investigate the relationship between nonalcoholic fatty liver disease ( NAFLD) and intima-media thickness( IMT) of carotid artery in type 2 diabetic patients with different ages.Methods A total of 211 type 2 diabetic patients including 113 with NAFLD and 98 without NAFLD were recruited.They were divided into three groups according to age. Clinical and biochemical data were compared between three groups.Results There was no significant correlation between NAFLD and IMT of carotid artery in the young group ( <45 years old) or the old group ( >60 years old)(P>0.05), but there existed a significant corre-lation in the middle-aged group (45~60 years old)(P<0.05).Conclusion NAFLD is one of the risk factors of carotid artery intima-media thickening in patients with type 2 diabetes.We should prevent and control arteriosclerosis in middle-aged patients with type 2 diabetes and NAFLD actively.And we should give anti-arteriosclerosis treatment to type 2 diabetics over 65 years old, with or without NAFLD.