CAJ | 학술논문

目的：获得一种新型人工骨，使其最大限度地接近自体骨，用于修复骨缺损。方法采用粒子溶出造孔法，用棒状谷氨酸钠晶体颗粒作为造孔剂，制备磷酸钙骨水泥三维多孔支架。测定不同制孔剂质量比复合材料的孔径、孔隙率与力学性能的关系；将浸泡后的样品烘干，在研钵体中研磨成粉体用X射线衍射仪进行物相分析；对支架材料进行扫描电镜观察。结果复合支架的孔隙率可达（80.2±2.2）％，孔隙直径100～600μm；复合纤维支架材料的强度提高了3～5倍，韧性明显增强（ P＜0.05）。结论谷氨酸钠晶体作为造孔剂安全有效，加入不同质量比可调控复合支架材料的孔隙率；聚磷酸钙纤维明显改善了复合支架材料的力学性能。
목적：획득일충신형인공골，사기최대한도지접근자체골，용우수복골결손。방법채용입자용출조공법，용봉상곡안산납정체과립작위조공제，제비린산개골수니삼유다공지가。측정불동제공제질량비복합재료적공경、공극솔여역학성능적관계；장침포후적양품홍간，재연발체중연마성분체용X사선연사의진행물상분석；대지가재료진행소묘전경관찰。결과복합지가적공극솔가체（80.2±2.2）％，공극직경100～600μm；복합섬유지가재료적강도제고료3～5배，인성명현증강（ P＜0.05）。결론곡안산납정체작위조공제안전유효，가입불동질량비가조공복합지가재료적공극솔；취린산개섬유명현개선료복합지가재료적역학성능。
Objective To obtain a new type of artificial bone,which is closest to the maximum of autogenous bone for repairing bone defects.Methods Macroporous calcium phosphate ce-ments ( CPC ) scaffold was prepared by a salt-leaching method using water-dissoluble rod-shaped monosodium glutamate crystals as poregen.The relationship between the porosity and the amount of poregen was investigated.The soaked sample was dried and grinded in a mortar into a powder body for phase analysis with X-ray diffraction.The scaffold was scanned by elec-tron microscopy.Results The porosity of CPC scaffold came up to ( 80.2 ±1.2 )% with a pore size range of 100~600μm.The compresive strength of the calcium polyphosphate ( CPP) fibers reinforced CPC scaffold increased 3 to 5 times higher than that of the CPC scaffold with-out fibers and the strain of fracture increased remarkably.Conclusion Sodium glutamate crys-tals as porous agent is safe and effective, joining different quality can control the porosity of composite scaffold materials; CPP fibers can enhance the mechanical properties of calcium phosphate cement.