CAJ | 학술논문

目的：研究急性缺血性脑卒中患者血清脂蛋白(a)水平及其与短期预后的关系。方法检测210例急性缺血性脑卒中患者以及100名性别和年龄匹配的健康人血清脂蛋白(a)水平。患者入院后行美国国立卫生研究院卒中量表(NIHSS)评定。出院时行改良Rankin量表(mRS)评定。结果患者组血清脂蛋白(a)水平显著高于健康人(P<0.001)。调整其他危险因素后，血清脂蛋白(a)水平是mRS的独立预测因素(P<0.001)。接受者操作特征曲线下面积分析，脂蛋白(a)和NIHSS联合模型的预测准确度高于NIHSS评分。结论急性缺血性脑卒中患者血清脂蛋白(a)水平升高。血清脂蛋白(a)水平是急性缺血性脑卒中短期预后的独立预测因素。
목적：연구급성결혈성뇌졸중환자혈청지단백(a)수평급기여단기예후적관계。방법검측210례급성결혈성뇌졸중환자이급100명성별화년령필배적건강인혈청지단백(a)수평。환자입원후행미국국립위생연구원졸중량표(NIHSS)평정。출원시행개량Rankin량표(mRS)평정。결과환자조혈청지단백(a)수평현저고우건강인(P<0.001)。조정기타위험인소후，혈청지단백(a)수평시mRS적독립예측인소(P<0.001)。접수자조작특정곡선하면적분석，지단백(a)화NIHSS연합모형적예측준학도고우NIHSS평분。결론급성결혈성뇌졸중환자혈청지단백(a)수평승고。혈청지단백(a)수평시급성결혈성뇌졸중단기예후적독립예측인소。
Objective To investigate the serum lipoprotein (Lp) (a) level in patients with acute ischemic stroke and the prediction for short-term functional outcome. Methods The levels of serum Lp(a) were measured in 210 patients with acute ischemic stroke (within 24 h after onset) and 100 healthy people matched the gender and age. The patients were assessed with National Institutes of Health Stroke Scale (NIHSS) as admission, and modified Rankin Scale (mRS) as discharge. Results The median of Lp(a) was 325 mg/L (IQR:180~545) in pa-tients, significantly more than 148 mg/L (IQR:69~265) in the normal controls (P<0.001). Level of serum Lp(a) was an independent variable for functional outcome (OR=1.004, 95%CI:1.001~1.007, P<0.001) and death (OR=1.006, 95%CI:1.001~1.008, P<0.001) in patients. In the receiver operating characteristic curve, the area under curve was more in the combined model [Lp(a) and NIHSS] than the NIHSS alone. Conclusion Serum Lp(a) increased in the in patients with acute ischemic stroke, and may predict the short-term outcome independently.