CAJ | 학술논문

阿尔茨海默病(AD)的主要病理变化之一是神经元内出现以磷酸化tau蛋白为主要成分的神经原纤维缠结。以往研究主要集中在老年斑及Aβ层面，近年来的研究表明，tau蛋白与AD的发生发展有着密切联系，tau蛋白异常磷酸化已成为目前的研究热点。本文从蛋白激酶及磷酸酶角度对tau蛋白磷酸化与AD之间的关系进行综述。
아이자해묵병(AD)적주요병리변화지일시신경원내출현이린산화tau단백위주요성분적신경원섬유전결。이왕연구주요집중재노년반급Aβ층면，근년래적연구표명，tau단백여AD적발생발전유착밀절련계，tau단백이상린산화이성위목전적연구열점。본문종단백격매급린산매각도대tau단백린산화여AD지간적관계진행종술。
Alzheimer's disease is a common neurodegenerative disease. One of the main pathology is neurofibrillary tangles in neurons, in which principal component is the phosphorylation of tau protein. Previous studies focused on senile plaques and Aβlevels. Recent studies indicated that the development of tau protein closely associated with Alzheimer's disease, especially the abnormal phosphorylation. This pa-per reviewed the relationship between tau protein phosphorylation and Alzheimer's disease based on the perspective of protein kinases and phosphatases.