CAJ | 학술논문

目的：应用多指标综合评分法结合正交设计，优选阿归养血颗粒油状物β-环糊精最佳包合工艺。方法以包合物油利用率、包合物含油率、包合物收得率为考察指标，经多指标综合评分法结合正交设计，考察油状物/β-环糊精（mL/g）、包合时间、包合温度、乙醇/油状物（%）等因素，最终确立阿归养血颗粒油状物β-环糊精最佳包合工艺。结果最佳包合工艺：即油状物/β-环糊精为1∶10，包合温度为40℃，乙醇/油状物为20%，包合1 h。结论采用多指标评分法结合正交设计优选得到阿归养血颗粒油状物最佳包合工艺，为阿归养血颗粒制备及相关研究提供了一定理论依据。
목적：응용다지표종합평분법결합정교설계，우선아귀양혈과립유상물β-배호정최가포합공예。방법이포합물유이용솔、포합물함유솔、포합물수득솔위고찰지표，경다지표종합평분법결합정교설계，고찰유상물/β-배호정（mL/g）、포합시간、포합온도、을순/유상물（%）등인소，최종학립아귀양혈과립유상물β-배호정최가포합공예。결과최가포합공예：즉유상물/β-배호정위1∶10，포합온도위40℃，을순/유상물위20%，포합1 h。결론채용다지표평분법결합정교설계우선득도아귀양혈과립유상물최가포합공예，위아귀양혈과립제비급상관연구제공료일정이론의거。
Objective To optimize the β-cyclodextrin inclusion process of Aguiyangxue particles under the application of multi-index comprehensive evaluation method combined with orthogonal experiment design. Methods Using the indexes of the rate of utilization of inclusion oil and the content of inclusion oil and the amount of the inclusion to investigate the oil-like substances/β-cyclodextrin(mL/g), inclusion time, inclusion temperature and ethanol/oil-like substances(%),and then to establish the optimicalβ-cyclodextrin inclusion process. Results The optimumβ-cyclodextrin inclusion process:the oil-like substances/β-cyclodextrin(mL/g) is 1∶10, inclusion temperature is 40℃, and inclusion time is 1 h, ethanol/oil-like substances (%) is 20%. Conclusion Theβ-cyclodextrin inclusion process of Aguiyangxue particles after the multi-index scores conbined with orthogonal experiment design provides a scientific basis for the clinical use.