CAJ | 학술논문

目的：比较维生素 D2注射液与维生素 D3注射液在治疗健康女性维生素 D 缺乏或不足时对血25羟维生素 D 水平的影响。方法选择常住成都市且年龄在40~55岁的健康女性94名，随机将其分为 D2组和 D3组各47例。D2组给予维生素 D2注射液，每次7.5mg（30万 U），每2周注射1次，共注射4次；D3组给予维生素 D3注射液，每次7.5mg（30万 U），每2周注射1次，共注射4次。分别于治疗前、最后1次注射后2周采静脉血测定血清25羟维生素 D，血清钙、磷、镁，血清甲状旁腺素（PTH）及血清骨源性碱性磷酸酶（BAP）。结果治疗后，D2组和 D3组血清25羟 D 水平明显升高，差异有统计学意义（P <0.01）；且治疗后 D3组25羟 D 水平高于 D2组，差异有统计学意义（P <0.01）。治疗前后，2组血清磷、血清 PTH 均降低，差异有统计学意义（P <0.01），血清钙、血清镁、血清 BAP 无明显变化，差异无统计学意义（P >0.05）。未出现维生素 D 中毒或药物相关不良反应表现。结论维生素 D 针剂无论是 D2还是 D3治疗维生素 D 缺乏或不足都是有效的，但在相同用法条件下 D3比 D2升高血清25羟 D 水平的幅度更大。维生素 D 注射剂30万 U 每2周1次共4次治疗维生素 D 不足或缺乏是安全的。
목적：비교유생소 D2주사액여유생소 D3주사액재치료건강녀성유생소 D 결핍혹불족시대혈25간유생소 D 수평적영향。방법선택상주성도시차년령재40~55세적건강녀성94명，수궤장기분위 D2조화 D3조각47례。D2조급여유생소 D2주사액，매차7.5mg（30만 U），매2주주사1차，공주사4차；D3조급여유생소 D3주사액，매차7.5mg（30만 U），매2주주사1차，공주사4차。분별우치료전、최후1차주사후2주채정맥혈측정혈청25간유생소 D，혈청개、린、미，혈청갑상방선소（PTH）급혈청골원성감성린산매（BAP）。결과치료후，D2조화 D3조혈청25간 D 수평명현승고，차이유통계학의의（P <0.01）；차치료후 D3조25간 D 수평고우 D2조，차이유통계학의의（P <0.01）。치료전후，2조혈청린、혈청 PTH 균강저，차이유통계학의의（P <0.01），혈청개、혈청미、혈청 BAP 무명현변화，차이무통계학의의（P >0.05）。미출현유생소 D 중독혹약물상관불량반응표현。결론유생소 D 침제무론시 D2환시 D3치료유생소 D 결핍혹불족도시유효적，단재상동용법조건하 D3비 D2승고혈청25간 D 수평적폭도경대。유생소 D 주사제30만 U 매2주1차공4차치료유생소 D 불족혹결핍시안전적。
Objective To compare the efficiency of vitamin D2 and vitamin D3 in raising the 25-hydroxyvitamin D (25(OH)D)status of female healthy adults working indoor. Methods 94 healthy women coming from Chengdu City and who were in 40 ~ 55 years old were randomly divided into Group D2(n = 47,treated with vitamin D2 injection 7. 5mg every two weeks for four times)and Group D3(n = 47,treated with D3 injection as the same way). The serum 25(OH)D,parathyroid hormone(PTH),bone alkaline phosphatase(BAP),serum calcium and phosphorus were measured before and after the inter-vention. Results After treatment,the average 25(OH)D level of Group D2、D3 increased significantly,the difference was sta-tistically significant(P < 0. 01). The 25(OH)D level of Group D3 was higher than Group D2 ,the difference was statistically significant(P < 0. 01). The PTH and serum phosphorus of both groups decreased,the difference was statistically significant (P < 0. 01). There were no significant change of serum calcium,BAP and serum magnesium(P > 0. 05). There was no vitamin D intoxication or related adverse reactions after intervention. Conclusion vitamin D2 and vitamin D3 are both effect,but Vita-min D3 injection is more efficient than Vitamin D2 injection in raising the 25-hydroxyvitamin D status of female healthy adults with vitamin D deficiency. The method that vitamin D 3 injection 300000 U every two weeks for four times is safe.