临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2014年
32期
7-8
,共2页
2 型糖尿病%门冬胰岛素 30%阿卡波糖%生物合成人胰岛素 R%地特胰岛素
2 型糖尿病%門鼕胰島素 30%阿卡波糖%生物閤成人胰島素 R%地特胰島素
2 형당뇨병%문동이도소 30%아잡파당%생물합성인이도소 R%지특이도소
Type 2 diabetes mellitus%NovoMix 30%Acarbose%Novolin R%Levemir
目的：比较单用门冬胰岛素（诺和锐）30血糖控制差的2型糖尿病患者加用阿卡波糖后和其改用四次胰岛素皮下注射方案的有效性、安全性。方法将医院60例单用诺和锐30血糖控制差的2型糖尿病患者随机分为2组，对照组30例采用诺和锐303次皮下注射同时3餐嚼服阿卡波糖；研究组30例采用4次胰岛素皮下注射（生物合成人胰岛素 R +地特胰岛素）。根据血糖调整胰岛素剂量，连续治疗12周后比较2组空腹血糖、餐后血糖、糖化血红蛋白（HbA1c）、胰岛素使用剂量及低血糖发生情况。结果2组空腹血糖，餐后血糖，HbA1c 都较前明显下降（P <0.05），但2组之间3项指标无明显统计学差异（P >0.05）；对照组胰岛素用量明显减少，且低血糖发生率低，差异均有统计学意义（P <0.05）。结论诺和锐30+阿卡波糖较4次胰岛素注射使血糖达标时所用的胰岛素量减少，并具有更少的低血糖发生率。
目的：比較單用門鼕胰島素（諾和銳）30血糖控製差的2型糖尿病患者加用阿卡波糖後和其改用四次胰島素皮下註射方案的有效性、安全性。方法將醫院60例單用諾和銳30血糖控製差的2型糖尿病患者隨機分為2組，對照組30例採用諾和銳303次皮下註射同時3餐嚼服阿卡波糖；研究組30例採用4次胰島素皮下註射（生物閤成人胰島素 R +地特胰島素）。根據血糖調整胰島素劑量，連續治療12週後比較2組空腹血糖、餐後血糖、糖化血紅蛋白（HbA1c）、胰島素使用劑量及低血糖髮生情況。結果2組空腹血糖，餐後血糖，HbA1c 都較前明顯下降（P <0.05），但2組之間3項指標無明顯統計學差異（P >0.05）；對照組胰島素用量明顯減少，且低血糖髮生率低，差異均有統計學意義（P <0.05）。結論諾和銳30+阿卡波糖較4次胰島素註射使血糖達標時所用的胰島素量減少，併具有更少的低血糖髮生率。
목적：비교단용문동이도소（낙화예）30혈당공제차적2형당뇨병환자가용아잡파당후화기개용사차이도소피하주사방안적유효성、안전성。방법장의원60례단용낙화예30혈당공제차적2형당뇨병환자수궤분위2조，대조조30례채용낙화예303차피하주사동시3찬작복아잡파당；연구조30례채용4차이도소피하주사（생물합성인이도소 R +지특이도소）。근거혈당조정이도소제량，련속치료12주후비교2조공복혈당、찬후혈당、당화혈홍단백（HbA1c）、이도소사용제량급저혈당발생정황。결과2조공복혈당，찬후혈당，HbA1c 도교전명현하강（P <0.05），단2조지간3항지표무명현통계학차이（P >0.05）；대조조이도소용량명현감소，차저혈당발생솔저，차이균유통계학의의（P <0.05）。결론낙화예30+아잡파당교4차이도소주사사혈당체표시소용적이도소량감소，병구유경소적저혈당발생솔。
Objective To compare the efficacy and safety between insulin aspart 30 injection( NovoMix 30)com-bined with acarbose and four-times-insulin subcutaneous injection in patients with poorly-controlled type 2 diabetes(T2DM) by alone NovoMix 30. Methods 60 cases of patients with poorly-controlled type 2 diabetes(T2DM)by alone NovoMix 30 were randomly divided into 2 groups. The control group was given NovoMix 30 subcutaneous injections,three times Daily,at the same time plus acarbose;the research group was given four subcutaneous insulin injections including biosynthetic human insu-lin injection(Novolin R)+ insulin detemir injection(Levemir). Adjust the dose of insulin according to the blood sugar. After 12 weeks of continuous treatment,the fasting blood sugar( FBS),postprandial blood glucose,glycosylated hemoglobin (HbA1c),the dose of insulin for daily use,and frequency of hypoglycemia of 2 groups were compared. Results The FBS, 2hPG,HbA1c of 2 groups were obviously decreased(P < 0. 05),but the three indicators were no significant statistical differ-ence between two groups(P > 0. 05);The control group significantly reduced the amount of insulin,with lower incidence of hy-poglycemia,the differences were statistical significance(P < 0. 05). Conclusion NovoMix 30 combined with acarbose re-duces the amount of insulin when the blood glucose control is at target,and has less incidence of hypoglycemia comparing with four-subcutaneous-insulin injections.
