CAJ | 학술논문

目的：探讨经皮穿刺放射性125 I粒子植入治疗体表难治性恶性肿瘤的局部疗效和副作用。方法2003年4月～2013年4月对105例（共123个部位）因体表难治性恶性肿瘤出现疼痛及肿瘤压迫等症状行经皮穿刺放射性粒子植入治疗，每1～2个月 CT 复查1次。结果105例共123个部位平均每个部位植入粒子13．6颗。局部疗效：CR 17．1％（21／123），PR 73．9％（91／123），NC 8．9％（11／123），总有效率（CR＋PR）91．1％（112／123）。局部疼痛缓解有效率88．8％（87／98），肿瘤压迫症状缓解率85．7％（18／21）。并发症发生率16．2％（17／105）：穿刺针道出血9例，治疗后肿瘤破溃4例，放射性皮炎2例，神经损伤1例，粒子脱落1例。结论125 I粒子植入治疗体表难治性恶性肿瘤微创、简单、安全、有效，对晚期患者可明显改善肿瘤的局部情况，减轻患者痛苦。
목적：탐토경피천자방사성125 I입자식입치료체표난치성악성종류적국부료효화부작용。방법2003년4월～2013년4월대105례（공123개부위）인체표난치성악성종류출현동통급종류압박등증상행경피천자방사성입자식입치료，매1～2개월 CT 복사1차。결과105례공123개부위평균매개부위식입입자13．6과。국부료효：CR 17．1％（21／123），PR 73．9％（91／123），NC 8．9％（11／123），총유효솔（CR＋PR）91．1％（112／123）。국부동통완해유효솔88．8％（87／98），종류압박증상완해솔85．7％（18／21）。병발증발생솔16．2％（17／105）：천자침도출혈9례，치료후종류파궤4례，방사성피염2례，신경손상1례，입자탈락1례。결론125 I입자식입치료체표난치성악성종류미창、간단、안전、유효，대만기환자가명현개선종류적국부정황，감경환자통고。
Objective To investigate the local efficacy as well as the complications of percutaneous radioactive 125 I seed implantation in the treatment of superficial refractory neoplasm. Methods A total of 105 patients ( 123 lesions ) diagnosed as having superficial refractory neoplasm from April 2003 to April 2013 was retrospectively collected. All patients were treated with percutaneous radioactive 125I seed implantation.Follow-up observations were conducted monthly or bi-monthly by CT scanning. Results The average number of implanted seed was 13.6 in the 105 patients.The local curative effects was as follows: CR 17.1%(21/123), PR 73.9%(91/123), NC 8.9%(11/123).The total effective rate (CR+PR) was 91.1% (112/123).The rate of relief from local pain was 88.8%(87/98).The rate of relief from pressure symptom was 85.7%(18/21).The complication rate was 16.2%(17/105), including bleeding of needle path in 9 cases, tumor rupture in 4 cases, radioactive dermatitis in 2 cases, nerve injury in 1 case, and seed displacement in 1 case. Conclusion Percutaneous radioactive 125 I seed implantation can significantly relieve the local symptoms, being a feasible, safe, and effective method for treating superficial refractory neoplasm.