CAJ | 학술논문

目的：研究纤维蛋白原在先兆子痫发病机制中的作用及其临床意义。方法回顾性分析了85例正常孕妇、47例轻度先兆子痫、27例重度子痫患者和55名健康未孕女性的血浆纤维蛋白原水平。采用受试者工作特征（ROC）曲线分析纤维蛋白原水平对先兆子痫的预测价值、以 Pearson 法分析纤维蛋白原水平与先兆子痫发生时间的关系。结果先兆子痫患者血浆纤维蛋白原水平较正常孕妇和未孕健康女性增高（P ＜0．01）。血浆纤维蛋白原预测轻度先兆子痫和重度先兆子痫的曲线下面积（95％可信区间）分别为0．70（0．62～0．78）和0．70（0．58～0．82）。血浆纤维蛋白原水平与发生先兆子痫的孕周呈负相关（R ＝-0．33，P ＜0．01）。结论血浆纤维蛋白原水平对预测先兆子痫具有一定的帮助。
목적：연구섬유단백원재선조자간발병궤제중적작용급기림상의의。방법회고성분석료85례정상잉부、47례경도선조자간、27례중도자간환자화55명건강미잉녀성적혈장섬유단백원수평。채용수시자공작특정（ROC）곡선분석섬유단백원수평대선조자간적예측개치、이 Pearson 법분석섬유단백원수평여선조자간발생시간적관계。결과선조자간환자혈장섬유단백원수평교정상잉부화미잉건강녀성증고（P ＜0．01）。혈장섬유단백원예측경도선조자간화중도선조자간적곡선하면적（95％가신구간）분별위0．70（0．62～0．78）화0．70（0．58～0．82）。혈장섬유단백원수평여발생선조자간적잉주정부상관（R ＝-0．33，P ＜0．01）。결론혈장섬유단백원수평대예측선조자간구유일정적방조。
Objective To investigate the pathogenetic role and clinical significance of fibrinogen in preeclampsia. Methods The medical records of 85 healthy pregnant women,47 mild preeclampsia pregnant patients,27 severe preeclampsia pregnant patients and 55 healthy women without pregnancy reviewed retrospectively.The predictive value of fibrinogen levels was assessed by receiver operating characteristic (ROC)curve.Pearson method was used to analyze the correlation between fibrinogen and the time of preeclampsia onset.Results Preeclampsia pregnant patients had higher plasma fibrinogen,compared with either healthy pregnant women or healthy women without pregnancy (P <0.01 ). The areas under ROC curve of fibrinogen for mild and severe preeclampsia [95% confidence interval (CI)]were 0.70 (0.62-0.78)and 0.70 (0.58-0.82).Negative correlation was observed between plasma fibrinogen and the time of preeclampsia onset (R =-0.33,P <0.01 ).Conclusions Plasma fibrinogen is helpful for preeclampsia prediction.