天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
11期
1114-1117
,共4页
陆卉%蔡英%张雅静%纪勇
陸卉%蔡英%張雅靜%紀勇
륙훼%채영%장아정%기용
脑梗死%血蛋白质类%血清白蛋白%红细胞分布宽度%mRS评分
腦梗死%血蛋白質類%血清白蛋白%紅細胞分佈寬度%mRS評分
뇌경사%혈단백질류%혈청백단백%홍세포분포관도%mRS평분
brain infarction%blood proteins%serum albumin%red cell distribution width%mRS score
目的:探讨脑梗死患者红细胞分布宽度及血浆白蛋白水平对脑梗死进展、预后及再发的影响。方法分析105例脑梗死患者临床资料,将病情在早期呈逐渐进展或阶梯式加重的患者归为进展型卒中组,其余归为完全型卒中组;根据脑梗死发生3个月、18个月后mRS评分情况分为短期和远期预后良好组及预后不良组;以18个月内是否再发脑梗死分再发组和未再发组。比较不同分组情况下患者的红细胞参数和血浆蛋白水平。结果进展型卒中组较完全型卒中组平均红细胞体积(fL:85.92±4.50 vs 83.79±4.64,t=2.164,P<0.05)、红细胞分布宽度(fL:13.50±2.45 vs 11.90±2.90,t=2.694,P<0.01)和球蛋白(g/L:27.46±4.33 vs 24.79±4.03,t=3.029,P<0.01)高,白蛋白低(g/L:39.00±3.86 vs 42.89±4.45,t=4.242,P<0.01),差异均有统计学意义;高红细胞分布宽度、低白蛋白水平是进展型卒中的危险因素;短期预后不良组红细胞分布宽度高于预后良好组(fL:13.90±2.45 vs 12.00±2.12,t=2.905,P<0.01);红细胞分布宽度与脑梗死3个月、18个月后mRS评分正相关(P<0.01)。结论高红细胞分布宽度和低白蛋白的脑梗死患者进展型卒中发生率增加,红细胞分布宽度对预测脑梗死预后具有一定的参考价值。
目的:探討腦梗死患者紅細胞分佈寬度及血漿白蛋白水平對腦梗死進展、預後及再髮的影響。方法分析105例腦梗死患者臨床資料,將病情在早期呈逐漸進展或階梯式加重的患者歸為進展型卒中組,其餘歸為完全型卒中組;根據腦梗死髮生3箇月、18箇月後mRS評分情況分為短期和遠期預後良好組及預後不良組;以18箇月內是否再髮腦梗死分再髮組和未再髮組。比較不同分組情況下患者的紅細胞參數和血漿蛋白水平。結果進展型卒中組較完全型卒中組平均紅細胞體積(fL:85.92±4.50 vs 83.79±4.64,t=2.164,P<0.05)、紅細胞分佈寬度(fL:13.50±2.45 vs 11.90±2.90,t=2.694,P<0.01)和毬蛋白(g/L:27.46±4.33 vs 24.79±4.03,t=3.029,P<0.01)高,白蛋白低(g/L:39.00±3.86 vs 42.89±4.45,t=4.242,P<0.01),差異均有統計學意義;高紅細胞分佈寬度、低白蛋白水平是進展型卒中的危險因素;短期預後不良組紅細胞分佈寬度高于預後良好組(fL:13.90±2.45 vs 12.00±2.12,t=2.905,P<0.01);紅細胞分佈寬度與腦梗死3箇月、18箇月後mRS評分正相關(P<0.01)。結論高紅細胞分佈寬度和低白蛋白的腦梗死患者進展型卒中髮生率增加,紅細胞分佈寬度對預測腦梗死預後具有一定的參攷價值。
목적:탐토뇌경사환자홍세포분포관도급혈장백단백수평대뇌경사진전、예후급재발적영향。방법분석105례뇌경사환자림상자료,장병정재조기정축점진전혹계제식가중적환자귀위진전형졸중조,기여귀위완전형졸중조;근거뇌경사발생3개월、18개월후mRS평분정황분위단기화원기예후량호조급예후불량조;이18개월내시부재발뇌경사분재발조화미재발조。비교불동분조정황하환자적홍세포삼수화혈장단백수평。결과진전형졸중조교완전형졸중조평균홍세포체적(fL:85.92±4.50 vs 83.79±4.64,t=2.164,P<0.05)、홍세포분포관도(fL:13.50±2.45 vs 11.90±2.90,t=2.694,P<0.01)화구단백(g/L:27.46±4.33 vs 24.79±4.03,t=3.029,P<0.01)고,백단백저(g/L:39.00±3.86 vs 42.89±4.45,t=4.242,P<0.01),차이균유통계학의의;고홍세포분포관도、저백단백수평시진전형졸중적위험인소;단기예후불량조홍세포분포관도고우예후량호조(fL:13.90±2.45 vs 12.00±2.12,t=2.905,P<0.01);홍세포분포관도여뇌경사3개월、18개월후mRS평분정상관(P<0.01)。결론고홍세포분포관도화저백단백적뇌경사환자진전형졸중발생솔증가,홍세포분포관도대예측뇌경사예후구유일정적삼고개치。
Objective To study the effect of red cell and plasma protein parameters on progression, prognosis and recurrence of cerebral infarction. Methods Clinical data from 105 patients with cerebral infarction were analyzed. The pa?tients were divided into four paired groups:progressive stroke group and complete stroke group, short-term favorable progno?sis group and short-term unfavorable prognosis group, long-term favorable prognosis group and long-term unfavorable prog?nosis group, relapsed cerebral infarction group and not relapsed group by different criterion. The red cell and plasma protein parameters were compared between groups. Results There were significantly higher mean corpuscular volume(fL:85.92± 4.50 vs 83.79±4.64,t=2.164,P<0.05), red cell distribution width(fL:13.50±2.45 vs 11.90±2.90,t=2.694,P<0.01), globu?lin(g/L:27.46±4.33 vs 24.79±4.03,t=3.029,P<0.01)and lower albumin(g/L:39.00±3.86 vs 42.89±4.45,t=4.242,P<0.01)in progressive stroke group than those of complete stroke group. The elevated red cell distribution width, reduced albu?min were the risk factors of progressive stroke. In the short-term unfavorable prognosis group, red cell distribution width was significantly higher than that in short-term favorable prognosis group(fL:13.90 ± 2.45 vs 12.00 ± 2.12,t=2.905,P<0.01). The red cell distribution width was positively correlated with mRS scores assessed 3 months and 18 months after cerebral in?farction(P<0.01). Conclusion Progressive stroke rate increases in cerebral infarction patients with elevated red cell distri?bution and reduced albumin;Red cell distribution width has a certain reference value for forecasting the prognosis of cere?bral infarction .