天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
11期
1100-1102
,共3页
何娟%刘戈力%刘婷婷%杨箐岩%郑荣秀
何娟%劉戈力%劉婷婷%楊箐巖%鄭榮秀
하연%류과력%류정정%양정암%정영수
格雷夫斯病%桥本病%促甲状腺激素受体刺激性抗体%促甲状腺激素受体刺激阻断性抗体%自身免疫甲状腺病%儿童
格雷伕斯病%橋本病%促甲狀腺激素受體刺激性抗體%促甲狀腺激素受體刺激阻斷性抗體%自身免疫甲狀腺病%兒童
격뢰부사병%교본병%촉갑상선격소수체자격성항체%촉갑상선격소수체자격조단성항체%자신면역갑상선병%인동
Graves disease%Hashimoto disease%TSAb%TSBAb%autoimmune thyroid disease%child
目的：探讨促甲状腺激素受体刺激性抗体（TSAb），促甲状腺激素受体刺激阻断性抗体（TSBAb）在儿童Graves病（GD）、桥本甲状腺炎（HT）诊治过程中的临床价值与意义。方法88例治疗时间小于6个月的自身免疫甲状腺病（AITD）儿童分为GD 55例（GD组）和HT 33例（HT组），选择同期健康儿童38例（正常组）作为对照。分别用人血清TSAb和TSBAb ELISA试剂盒检测3组血清TSAb、TSBAb的水平，比较3组血清TSAb、TSBAb的差异，并分析血清TSAb、TSBAb之间的相关性及其与血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、超敏促甲状腺素（TSH）的关系。结果 GD组血清TSAb水平高于HT组和正常组（均P<0.05）；HT组血清TSBAb水平高于正常组（P<0.05）；血清TSAb与TSBAb无相关性（P>0.05），血清TSAb、TSBAb与FT3、FT4、TSH均无相关性（均P>0.05）。结论 TSAb、TSBAb分别与儿童GD、HT的发病密切相关，在GD和HT的诊断和治疗中有重要的临床价值。
目的：探討促甲狀腺激素受體刺激性抗體（TSAb），促甲狀腺激素受體刺激阻斷性抗體（TSBAb）在兒童Graves病（GD）、橋本甲狀腺炎（HT）診治過程中的臨床價值與意義。方法88例治療時間小于6箇月的自身免疫甲狀腺病（AITD）兒童分為GD 55例（GD組）和HT 33例（HT組），選擇同期健康兒童38例（正常組）作為對照。分彆用人血清TSAb和TSBAb ELISA試劑盒檢測3組血清TSAb、TSBAb的水平，比較3組血清TSAb、TSBAb的差異，併分析血清TSAb、TSBAb之間的相關性及其與血清遊離三碘甲狀腺原氨痠（FT3）、遊離甲狀腺素（FT4）、超敏促甲狀腺素（TSH）的關繫。結果 GD組血清TSAb水平高于HT組和正常組（均P<0.05）；HT組血清TSBAb水平高于正常組（P<0.05）；血清TSAb與TSBAb無相關性（P>0.05），血清TSAb、TSBAb與FT3、FT4、TSH均無相關性（均P>0.05）。結論 TSAb、TSBAb分彆與兒童GD、HT的髮病密切相關，在GD和HT的診斷和治療中有重要的臨床價值。
목적：탐토촉갑상선격소수체자격성항체（TSAb），촉갑상선격소수체자격조단성항체（TSBAb）재인동Graves병（GD）、교본갑상선염（HT）진치과정중적림상개치여의의。방법88례치료시간소우6개월적자신면역갑상선병（AITD）인동분위GD 55례（GD조）화HT 33례（HT조），선택동기건강인동38례（정상조）작위대조。분별용인혈청TSAb화TSBAb ELISA시제합검측3조혈청TSAb、TSBAb적수평，비교3조혈청TSAb、TSBAb적차이，병분석혈청TSAb、TSBAb지간적상관성급기여혈청유리삼전갑상선원안산（FT3）、유리갑상선소（FT4）、초민촉갑상선소（TSH）적관계。결과 GD조혈청TSAb수평고우HT조화정상조（균P<0.05）；HT조혈청TSBAb수평고우정상조（P<0.05）；혈청TSAb여TSBAb무상관성（P>0.05），혈청TSAb、TSBAb여FT3、FT4、TSH균무상관성（균P>0.05）。결론 TSAb、TSBAb분별여인동GD、HT적발병밀절상관，재GD화HT적진단화치료중유중요적림상개치。
Objective To study clinical value and significance of thyroid receptor stimulating antibody (TSAb) and thyroid stimulating-blocking antibody (TSBAb) on diagnosis and treatment for children with Graves’disease (GD) and Hashimoto’s thyroiditis (HT). Methods Eighty-eight children with autoimmune thyroid disease (AITD) and treatment time less six months were divided into GD group (n=55) and HT group (n=33). Thirty-eight healthy children were used as control (Normal group). Human serum TSAb ELISA kit and human TSBAb ELISA kit were used to detect the serum TSAb and serum TSBAb in three groups. The serum levels of TSAb and TSBAb were compared between three groups. The correla? tion between TSAb and TSBAb, TSAb/TSBAb and free triiodothyronine three (FT3), free thyroxine (FT4), ultra sensitive thy?roid stimulating hormone (TSH) were analyzed. Results The serum level of TSAb was significantly higher in GD group than that of HT group and Normal group (P<0.05). The serum level of TSBAb was significantly higher in HT group than that of Normal group (P<0.05). There was no significant correlation between serum TSAb and serum TSBAb (P>0.05). There were no significant correlation between serum TSAb, TSBAb and FT3, FT4, TSH (P>0.05). Conclusion TSAb and TSBAb are related to the pathogenesis of GD and HT in children. TSAb and TSBAb have an important clinical value in the diagnosis and treatment for children with GD and HT.
