CAJ | 학술논문

皮质发育畸形%磁共振成像%脑电描记术%正电子发射断层显像术%静息态磁共振脑功能成像%局部一致性%低频振幅%低频振幅分数皮質髮育畸形%磁共振成像%腦電描記術%正電子髮射斷層顯像術%靜息態磁共振腦功能成像%跼部一緻性%低頻振幅%低頻振幅分數
피질발육기형%자공진성상%뇌전묘기술%정전자발사단층현상술%정식태자공진뇌공능성상%국부일치성%저빈진폭%저빈진폭분수
malformations of cortical development%magnetic resonance imaging%electroencephalography%positron-emission tomography%resting state-fMRI%regional homogeneity%amplitude of low-frequency fluctuation%fractional of ALFF

目的：探讨基于局部一致性（ReHo）、低频振幅（ALFF）和低频振幅分数（fALFF）的静息态功能MRI （RS-fMRI）是否具有术前定位皮质发育畸形（MCD）患者致灶的能力。方法 MCD患者10例行RS-fMRI检查，静息态数据经预处理和分析后得到的ReHo、ALFF和fALFF激活图，与视频脑电图（VEEG）、正电子发射断层显像（PET）、MRI及综合评估的致灶结果比较。比较患者术后结果与静息态异常激活图结果。结果 RS-fMRI致灶定位结果分别与6例VEEG、8例PET、6例MRI以及7例最终综合评估的致灶定位结果一致。6例接受手术治疗的患者（包括2例MRI检查阴性）均发现异常的局部激活图，术后经病理证实为皮质发育畸形（2例灰质异位和4例局灶性皮质发育不良）。结论基于ReHo、ALFF及fALFF分析方法的RS-fMRI具有定位MCD患者致灶的能力。
목적：탐토기우국부일치성（ReHo）、저빈진폭（ALFF）화저빈진폭분수（fALFF）적정식태공능MRI （RS-fMRI）시부구유술전정위피질발육기형（MCD）환자치조적능력。방법 MCD환자10례행RS-fMRI검사，정식태수거경예처리화분석후득도적ReHo、ALFF화fALFF격활도，여시빈뇌전도（VEEG）、정전자발사단층현상（PET）、MRI급종합평고적치조결과비교。비교환자술후결과여정식태이상격활도결과。결과 RS-fMRI치조정위결과분별여6례VEEG、8례PET、6례MRI이급7례최종종합평고적치조정위결과일치。6례접수수술치료적환자（포괄2례MRI검사음성）균발현이상적국부격활도，술후경병리증실위피질발육기형（2례회질이위화4례국조성피질발육불량）。결론기우ReHo、ALFF급fALFF분석방법적RS-fMRI구유정위MCD환자치조적능력。
Objective To investigate whether resting state-fMRI (RS-fMRI) based on local consistency (ReHo), am?plitude low-frequency fluctuate (ALFF) and fALFF can add meaningful information on preoperative localization of epilepto?genic zone in patients with malformations of cortical development (MCD). Methods Ten epilepsy patients with MCD were studied with RS-fMRI using a 3.0 T scanner. The resting state data were preprocessed and analyzed using SPM8 and REST to generate the activation map. Abnormal ReHo, ALFF and fALFF related blood oxygen level dependent (BOLD) signal changes were compared to video EEG (VEEG),PET,MRI findings and the final result of a comprehensive evaluation-de?fined epileptogenic zone. For operated patients, postoperative resection and histology were compared to BOLD responses. Re?sults The results of spike localization of RS-fMRI were consistent with VEEG, PET, MRI findings and final comprehensive evaluation-defined epileptogenic zone in 6, 8, 6, 7 of 10 investigations. Six operated patients (including two negative results of MRI examination) revealed local abnormal changes but not visible on structural MRI, which was confirmed cortical malfor?mations by pathology after operation (2 heterotopia and 4 cortical dysplasia). Conclusion RS-fMRI may help to delineate the epileptic focus in epilepsy patients with MCD.