CAJ | 학술논문

目的：比较盖三醇与罗盖全在治疗尿毒症患者继发性甲状旁腺功能亢进的疗效，选择经济、有效的治疗药物。方法：对22例尿毒症继发性甲状旁腺功能亢进患者检测iPTH＞300pg／ml，随机分为2组，根据血iPTH水平确定剂量，分别口服盖三醇与罗盖全冲击治疗，测定两组治疗前后的 iPTH、血钙、血磷，监测不良反应。结果：治疗12周两组患者iPTH均有不同程度下降，A、B组iPTH达标率分别为81．8％，72．7％，与治疗前比较差异有统计学意义，治疗12周时 A、B组血清iPTH比较差异无统计学意义，两组血钙、磷水平变化不大，不良反应轻。两组治疗费用有显著差异。结论：盖三醇与罗盖全在冲击继发性甲状旁腺功能亢进时均安全有效，无显著差别，其不良反应均轻微，但国产药物治疗费用明显降低，故选择盖三醇符合国情：经济、实惠、有效，减轻患者费用。
목적：비교개삼순여라개전재치료뇨독증환자계발성갑상방선공능항진적료효，선택경제、유효적치료약물。방법：대22례뇨독증계발성갑상방선공능항진환자검측iPTH＞300pg／ml，수궤분위2조，근거혈iPTH수평학정제량，분별구복개삼순여라개전충격치료，측정량조치료전후적 iPTH、혈개、혈린，감측불량반응。결과：치료12주량조환자iPTH균유불동정도하강，A、B조iPTH체표솔분별위81．8％，72．7％，여치료전비교차이유통계학의의，치료12주시 A、B조혈청iPTH비교차이무통계학의의，량조혈개、린수평변화불대，불량반응경。량조치료비용유현저차이。결론：개삼순여라개전재충격계발성갑상방선공능항진시균안전유효，무현저차별，기불량반응균경미，단국산약물치료비용명현강저，고선택개삼순부합국정：경제、실혜、유효，감경환자비용。
Objective:To observe the clinical curative effect of Gai Sanchun and Luo Gaiquan in treating secondary hyperparathyroidism in uremic patients, and drug selection and economic,effective.Methods:22 cases of uremic patients with secondary hyperparathyroidism (PTH>300pg/ml),were randomly di-vided into two groups,determine the dose according to the level of blood PTH,were treated with Gai Sanchun and Luo Gaiquan shock therapy.Serum PTH, serum calcium,phosphorus were determined in two groups before and after treatment,adverse reaction monitoring.Results:After treatment of 12 weeks, two groups of patients with PTH were decreased,A and B group PTH standard rate were 81.8%,72.7%,The levels of serum PTH decreased significantly after treatment in group A and B,to compare A and B group there was no significant difference in serum PTH,two group of calcium,phosphorus level had no obviously difference,less adverse reactions.Conclusion:Gai Sanchun and Luo Gaiquan were safe and effective in the impact of secondary hyperparathyroid-ism,there was no significant difference,and the adverse reactions were slight,the choice of Gai Sanchun conforms to the conditions:economic,practical, effective,reducing costs for patients.