大家健康（下旬版）
大傢健康（下旬版）
대가건강（하순판）
FOR ALL HEALTH
2014年
11期
12-12,13
,共2页
微生态制剂%新生儿坏死性小肠结肠炎%早产儿
微生態製劑%新生兒壞死性小腸結腸炎%早產兒
미생태제제%신생인배사성소장결장염%조산인
microecological preparation%neonatal necrotizing enterocolities premature infant
目的：观察应用双歧杆菌制剂预防早产儿坏死性小肠结肠炎（NEC）的临床床效果。方法：将2011年1月-2012年1月在本院住院的328例早产儿按病例对照研究分成2组（预防组、对照组），2组除病因治疗、合理喂养外，预防组在24 h内加双歧杆菌制剂164服。应用X2检验或确切概率法比较2组不同胎龄、不同出生质量早产儿 NEC患病率的差异。结果：预防组164例中5例诊断为NEC，患病率为3．05％；对照组164例中21例诊断为NEC，患病率为12．80％。预防组早产儿的 NEC患病率明显低于对照组（X2＝8．60，P＜0．05）。胎龄＜32周早产儿，2组 NEC患病率比较差异无统计学意义（X2＝0．36，P＞0．10）。2组极低出生体质量早产儿 NEC患病率比较差异无统计学意义（P＝0．62）；2组低出生体质量早产儿 NEC患病率比较差异有统计学意义（X2＝11．48，P＜0．05）。结论：预防性应用微生态制剂双歧杆菌制剂可明显降低早产儿 NEC的患病率，可能与双歧杆菌制剂可促进早产儿肠道正常菌群的定植和优势化有关。微生态制剂预防性保护作用随胎龄减小有渐减趋势。
目的：觀察應用雙歧桿菌製劑預防早產兒壞死性小腸結腸炎（NEC）的臨床床效果。方法：將2011年1月-2012年1月在本院住院的328例早產兒按病例對照研究分成2組（預防組、對照組），2組除病因治療、閤理餵養外，預防組在24 h內加雙歧桿菌製劑164服。應用X2檢驗或確切概率法比較2組不同胎齡、不同齣生質量早產兒 NEC患病率的差異。結果：預防組164例中5例診斷為NEC，患病率為3．05％；對照組164例中21例診斷為NEC，患病率為12．80％。預防組早產兒的 NEC患病率明顯低于對照組（X2＝8．60，P＜0．05）。胎齡＜32週早產兒，2組 NEC患病率比較差異無統計學意義（X2＝0．36，P＞0．10）。2組極低齣生體質量早產兒 NEC患病率比較差異無統計學意義（P＝0．62）；2組低齣生體質量早產兒 NEC患病率比較差異有統計學意義（X2＝11．48，P＜0．05）。結論：預防性應用微生態製劑雙歧桿菌製劑可明顯降低早產兒 NEC的患病率，可能與雙歧桿菌製劑可促進早產兒腸道正常菌群的定植和優勢化有關。微生態製劑預防性保護作用隨胎齡減小有漸減趨勢。
목적：관찰응용쌍기간균제제예방조산인배사성소장결장염（NEC）적림상상효과。방법：장2011년1월-2012년1월재본원주원적328례조산인안병례대조연구분성2조（예방조、대조조），2조제병인치료、합리위양외，예방조재24 h내가쌍기간균제제164복。응용X2검험혹학절개솔법비교2조불동태령、불동출생질량조산인 NEC환병솔적차이。결과：예방조164례중5례진단위NEC，환병솔위3．05％；대조조164례중21례진단위NEC，환병솔위12．80％。예방조조산인적 NEC환병솔명현저우대조조（X2＝8．60，P＜0．05）。태령＜32주조산인，2조 NEC환병솔비교차이무통계학의의（X2＝0．36，P＞0．10）。2조겁저출생체질량조산인 NEC환병솔비교차이무통계학의의（P＝0．62）；2조저출생체질량조산인 NEC환병솔비교차이유통계학의의（X2＝11．48，P＜0．05）。결론：예방성응용미생태제제쌍기간균제제가명현강저조산인 NEC적환병솔，가능여쌍기간균제제가촉진조산인장도정상균군적정식화우세화유관。미생태제제예방성보호작용수태령감소유점감추세。
Objective:To explore the preventive effects of microecologicnl preparation(Jinshuangqi)on neonatal necmtizing enterocolid8(NEC)in prema-ture infants.Methods:The 328 cases of premature infants from during May 2010 to Feb.2012 were divided into prevention group and control group with matching.The prevention group WaS added with Jinshuangqi tablets in 24 hours and continued tO be treated for the primary disease,while the control one Wag only treated for the primary disease.The incidence of NEC between the different gestation or different birth weight premature of the 2 groups were com-pared by using Chi-Square test or exact probabihty.Results:There was 21 case of NEC in the control group(12.80%),but only 5case in the prevention group(3.05%).Compared with the control group,the incidence rate of NEC in prevention group Wag significantly lower (X2=8.60,P<0.05),while that of the infants before 32 weeks of gestation had no significant difference between 2 groupsh2(X2=0.36,P>0.10).There Wag significant differen in the prema-ture infants of low birth weight in the incidence rate of NEC(X2=11.48,P<0.05),but the rate of NEC between the premature infants of very low birth weight of2 groups had no significant difference(P=0.62).Conclusions:Using microecologieal preparation Can clearly declreagethe incidence rate of NECin premature.Supplementing the microecologieal preparation to infants early would enable normal flora to inhabitthe surface of mucous member.as the biologi-cal barrier will prevent the invasion of germs.The protection of the supplemented microecologieal preparation tend to decrease as the gestation age became smaller.
