现代消化及介入诊疗
現代消化及介入診療
현대소화급개입진료
MODERN DIGESTION & INTERVENTION
2014年
5期
294-296,299
,共4页
复方苦参注射液%消化系统肿瘤%化疗
複方苦參註射液%消化繫統腫瘤%化療
복방고삼주사액%소화계통종류%화료
Compound kushen injection%Digestive system cancer%Chemotherapy
目的：研究复方苦参注射液对中晚期消化系统肿瘤患者的化疗疗效、不良反应、镇痛效果及生活质量的影响。方法将病理诊断的76例中晚期消化系统肿瘤患者随机分成实验组和对照组，每组38例，实验组在与对照组应用同样常规化疗的基础之上加用复方苦参注射液，连续应用两个疗程后进行评价。结果实验组与对照组在2个疗程后的疗效比较差异（P＞0.05）无统计学意义；治疗过程中两组在不良反应白细胞计数下降和恶心、呕吐方面的差异有统计学意义（P＜0.05），而在碱性磷酸酶和脱发方面的差异无统计学意义（P＞0.05）；治疗后两组镇痛效果差异有统计学意义（P＜0.05）；两组在生活质量比较的差异有统计学意义（P＜0.05）。结论复方苦参注射液在中晚期消化系统肿瘤化疗时起到改善患者生活质量，减少骨髓抑制，减轻胃肠道反应及一定程度镇痛的作用。
目的：研究複方苦參註射液對中晚期消化繫統腫瘤患者的化療療效、不良反應、鎮痛效果及生活質量的影響。方法將病理診斷的76例中晚期消化繫統腫瘤患者隨機分成實驗組和對照組，每組38例，實驗組在與對照組應用同樣常規化療的基礎之上加用複方苦參註射液，連續應用兩箇療程後進行評價。結果實驗組與對照組在2箇療程後的療效比較差異（P＞0.05）無統計學意義；治療過程中兩組在不良反應白細胞計數下降和噁心、嘔吐方麵的差異有統計學意義（P＜0.05），而在堿性燐痠酶和脫髮方麵的差異無統計學意義（P＞0.05）；治療後兩組鎮痛效果差異有統計學意義（P＜0.05）；兩組在生活質量比較的差異有統計學意義（P＜0.05）。結論複方苦參註射液在中晚期消化繫統腫瘤化療時起到改善患者生活質量，減少骨髓抑製，減輕胃腸道反應及一定程度鎮痛的作用。
목적：연구복방고삼주사액대중만기소화계통종류환자적화료료효、불량반응、진통효과급생활질량적영향。방법장병리진단적76례중만기소화계통종류환자수궤분성실험조화대조조，매조38례，실험조재여대조조응용동양상규화료적기출지상가용복방고삼주사액，련속응용량개료정후진행평개。결과실험조여대조조재2개료정후적료효비교차이（P＞0.05）무통계학의의；치료과정중량조재불량반응백세포계수하강화악심、구토방면적차이유통계학의의（P＜0.05），이재감성린산매화탈발방면적차이무통계학의의（P＞0.05）；치료후량조진통효과차이유통계학의의（P＜0.05）；량조재생활질량비교적차이유통계학의의（P＜0.05）。결론복방고삼주사액재중만기소화계통종류화료시기도개선환자생활질량，감소골수억제，감경위장도반응급일정정도진통적작용。
Objective To evaluate the efficacy, adverse reaction, analgesic effect, and quality of life of patients with digestive system mid-advanced cancer with compound kushen injection during chemotherapy. Methods Seventy six cancer patients diagnosed by pathology were randomly assigned to the experimental and control groups, 38 patients of each group. The patients in control group took the conventional chemotherapy drugs, and the patients in experimental group added the compound kushen injection on the basis of convention-al chemotherapy equal to the control group. The two groups were evaluated after two courses of continuous treatment. Results The outcome of difference was no statistical significance after two courses of treatment (P>0.05). Leukocytopenia, nausea and vomiting in experimental group were significantly less severe than in con-trol group(P<0.05). There was no significant difference between two groups in terms of alkaline phosphatase increase and hair loss(P>0.05). Patients in experimental group had better analgesic effect after treatment than patients in control group (P<0.05). Patients in experimental group also had better quality of life (P<0.05). Conclusions The compound kushen injection can play a part role in improving the quality of life of patients, alleviating bone marrow suppression during chemotherapy.
