现代消化及介入诊疗
現代消化及介入診療
현대소화급개입진료
MODERN DIGESTION & INTERVENTION
2014年
5期
281-284
,共4页
曹友红%马平%王福根%许春芳
曹友紅%馬平%王福根%許春芳
조우홍%마평%왕복근%허춘방
CDK4%周期素依赖性激酶4%胃癌%免疫组织化学
CDK4%週期素依賴性激酶4%胃癌%免疫組織化學
CDK4%주기소의뢰성격매4%위암%면역조직화학
CDK4%Cyclin dependent kinase 4%Gastric cancer%Immunohischemistry
目的:研究CDK4在胃癌组织中的表达与临床病理特征之间的关系。方法采用免疫组化方法检测CDK4在70例胃癌组织及部分相应癌旁组织中的表达,结合患者的性别、年龄、肿瘤大小、部位、分化程度、Borrmann分型、浸润深度、淋巴结转移和TNM分期等临床病理参数进行综合分析。结果胃癌组织和癌旁组织中的CDK4蛋白阳性表达分别为65.71%、18.75%,差异有统计学意义(P<0.05)。CDK4在低分化组阳性表达率为78.05%(32/41),中高分化组阳性表达率为48.28%(14/29),两组间比较差异有统计学差异(P<0.05,χ2=6.693);CDK4在无淋巴结转移组中阳性表达率为44.83%(13/29),有淋巴结转移组中阳性表达率为80.49%(33/41),两者间比较有显著统计学差异(P<0.01,χ2=9.587);CDK4在Ⅰ+Ⅱ期阳性表达率为53.13%(17/32),Ⅲ+Ⅳ期组阳性表达率为76.32%(29/38),两组间比较差异有统计学差异(P<0.05,χ2=4.147);CDK4蛋白阳性表达与患者的性别、年龄、肿瘤大小、部位、Borrmann分型、浸润深度均无明显相关(P>0.05)。结论 CDK4在胃癌组织中存在着过表达,在评估胃癌的发生、发展中有一定的临床价值。CDK4表达水平与肿瘤组织分化程度、淋巴结有无转移、TNM分期有关。
目的:研究CDK4在胃癌組織中的錶達與臨床病理特徵之間的關繫。方法採用免疫組化方法檢測CDK4在70例胃癌組織及部分相應癌徬組織中的錶達,結閤患者的性彆、年齡、腫瘤大小、部位、分化程度、Borrmann分型、浸潤深度、淋巴結轉移和TNM分期等臨床病理參數進行綜閤分析。結果胃癌組織和癌徬組織中的CDK4蛋白暘性錶達分彆為65.71%、18.75%,差異有統計學意義(P<0.05)。CDK4在低分化組暘性錶達率為78.05%(32/41),中高分化組暘性錶達率為48.28%(14/29),兩組間比較差異有統計學差異(P<0.05,χ2=6.693);CDK4在無淋巴結轉移組中暘性錶達率為44.83%(13/29),有淋巴結轉移組中暘性錶達率為80.49%(33/41),兩者間比較有顯著統計學差異(P<0.01,χ2=9.587);CDK4在Ⅰ+Ⅱ期暘性錶達率為53.13%(17/32),Ⅲ+Ⅳ期組暘性錶達率為76.32%(29/38),兩組間比較差異有統計學差異(P<0.05,χ2=4.147);CDK4蛋白暘性錶達與患者的性彆、年齡、腫瘤大小、部位、Borrmann分型、浸潤深度均無明顯相關(P>0.05)。結論 CDK4在胃癌組織中存在著過錶達,在評估胃癌的髮生、髮展中有一定的臨床價值。CDK4錶達水平與腫瘤組織分化程度、淋巴結有無轉移、TNM分期有關。
목적:연구CDK4재위암조직중적표체여림상병리특정지간적관계。방법채용면역조화방법검측CDK4재70례위암조직급부분상응암방조직중적표체,결합환자적성별、년령、종류대소、부위、분화정도、Borrmann분형、침윤심도、림파결전이화TNM분기등림상병리삼수진행종합분석。결과위암조직화암방조직중적CDK4단백양성표체분별위65.71%、18.75%,차이유통계학의의(P<0.05)。CDK4재저분화조양성표체솔위78.05%(32/41),중고분화조양성표체솔위48.28%(14/29),량조간비교차이유통계학차이(P<0.05,χ2=6.693);CDK4재무림파결전이조중양성표체솔위44.83%(13/29),유림파결전이조중양성표체솔위80.49%(33/41),량자간비교유현저통계학차이(P<0.01,χ2=9.587);CDK4재Ⅰ+Ⅱ기양성표체솔위53.13%(17/32),Ⅲ+Ⅳ기조양성표체솔위76.32%(29/38),량조간비교차이유통계학차이(P<0.05,χ2=4.147);CDK4단백양성표체여환자적성별、년령、종류대소、부위、Borrmann분형、침윤심도균무명현상관(P>0.05)。결론 CDK4재위암조직중존재착과표체,재평고위암적발생、발전중유일정적림상개치。CDK4표체수평여종류조직분화정도、림파결유무전이、TNM분기유관。
Objective This study was designed to delineate the expression and significance of CDK4 in gastric cancer. Methods The expressions of CDK4 protein were detected by immunohischemistry in 70 cases of gastric cancer tissues and matched partly adjacent tissues. The levels of the expression were analyzed com-bining with clinicopathological parameters of the patients including age, gender, tumor diameter, site, differen-tiation, Borrmann type, infiltration depth, lymph node metastasis and TNM stage. Results In gastric cancer and its partly adjacent tissues, CDK4 was positive in 46 cases (65.71%) and 6 cases (18.75%) respectively, the difference was statistically significant (P<0.05). In the poorly differentiated group and the well-moderately differentiated group, CDK4 was positive in 32 cases (78.05%) and 14 cases (48.28%), respectively (P<0.05). In non-lymph node metastasis group and the lymph node metastasis group, the CDK4 was positive in 13 cases (44.83%) and 33 cases (80.49%), respectively (P<0.05). According to TNM staging, CDK4 was positive in 17 cases (53.13%) in stageⅠ+Ⅱgroup, and 29 cases (76.32%) in stageⅢ+Ⅳgroup, respectively (P<0.05). The expression of CDK4 was not associated with patient′s gender, age, tumor size, location, Borrmann type and infiltration depth (P>0.05). Conclusions Over-expression of CDK4 exists in gastric cancer, and there is a good relationship between expression of CDK4 and tumor differentiation,lymph node metastasis, and TNM stage. The over-expression of CDK4 in gastric cancer is of great clinical value in evaluating the development of gastric cancer.