CAJ | 학술논문

目的：探讨分化抑制因子-1(Id-1)蛋白在肾透明细胞癌(RCCC)中的表达及其临床意义。方法应用免疫组化二步法检测76例 RCCC 组织、29例癌旁正常组织中 Id-1蛋白的表达情况,分析 Id-1蛋白与患者临床病理特征及术后生存率之间的关系。结果 Id-1在 RCCC 组织和癌旁正常组织中的阳性表达率分别为90.8%、17.2%,二者比较差异有统计学意义(P <0.05),且Id-1的表达程度与肿瘤的病理分级、TNM 分期相关(P <0.05),但与患者性别、年龄、有无复发等无明显相关性(P >0.05)；生存分析显示 Id-1表达阳性和阴性患者的5年生存率分别为23.5%、56.0%,两组生存率差异有统计学意义(P =0.017)。结论 Id-1的表达在 RCCC 中增高,Id-1阳性患者的预后较差,Id-1可作为 RCCC 诊断和预后判断的有效辅助指标。
목적：탐토분화억제인자-1(Id-1)단백재신투명세포암(RCCC)중적표체급기림상의의。방법응용면역조화이보법검측76례 RCCC 조직、29례암방정상조직중 Id-1단백적표체정황,분석 Id-1단백여환자림상병리특정급술후생존솔지간적관계。결과 Id-1재 RCCC 조직화암방정상조직중적양성표체솔분별위90.8%、17.2%,이자비교차이유통계학의의(P <0.05),차Id-1적표체정도여종류적병리분급、TNM 분기상관(P <0.05),단여환자성별、년령、유무복발등무명현상관성(P >0.05)；생존분석현시 Id-1표체양성화음성환자적5년생존솔분별위23.5%、56.0%,량조생존솔차이유통계학의의(P =0.017)。결론 Id-1적표체재 RCCC 중증고,Id-1양성환자적예후교차,Id-1가작위 RCCC 진단화예후판단적유효보조지표。
Objective Study the expression of Id-1 protein in renal clear cell carcinoma (RCCC) and analyze the clinical significance. Methods Immunohistochemistry were used to detect the level of Id-1 protein in 76 RCCC tissues and 29 normal renal tissues.The relationship between Id-1 expression level and clinical pathological data were analyzed.Survival analyses was carried in Kaplan-Meier method. Re-sults The expression level of Id-1 protein in RCCC and normal renal tissues were 90.8%,1 7.2%respectively,they had significant difference (P < 0.05 ).Positive rates of Id-1 was correlated with the pathological grade and clinical stages of RCCC (P <0.05),but not with age,sex,and recurrence (P >0.05).The five-year survival rate of Id-1-positive and negative patients was 23.5%,56.0% re-spectively,the two groups had significant difference (P <0.05). Conclusions The expression of Id-1 is higher in RCCC tissues,the prognosis of Id-1-positive patients were poor,Id-1 may be a use-ful biomarker for diagnosing,treating RCCC and evaluating its prognosis.