CAJ | 학술논문

目的：比较埃索美拉唑与法莫替丁对长期服用非甾体类抗炎药（ NSAIDs ）患者防治胃粘膜损伤的临床疗效。方法选择长期服用NSAIDs的127例风湿性疾病及骨关节疾病患者为研究对象，随机分为观察组67例和对照组60例。观察组服用埃索美拉唑治疗，对照组服用法莫替丁治疗。两组疗程均为3个月，比较上消化道症状发生率、胃粘膜损伤发生率及治疗前后胃液pH值变化。结果观察组上消化道症状发生率、胃粘膜损伤发生率均低于对照组（ P ＜0．05）；观察组治疗后胃液pH值高于对照组（ P ＜0．01）。结论埃索美拉唑能有效缓解长期服用NSAIDs患者上消化道症状，防治胃粘膜损伤，整体疗效优于法莫替丁。
목적：비교애색미랍서여법막체정대장기복용비치체류항염약（ NSAIDs ）환자방치위점막손상적림상료효。방법선택장기복용NSAIDs적127례풍습성질병급골관절질병환자위연구대상，수궤분위관찰조67례화대조조60례。관찰조복용애색미랍서치료，대조조복용법막체정치료。량조료정균위3개월，비교상소화도증상발생솔、위점막손상발생솔급치료전후위액pH치변화。결과관찰조상소화도증상발생솔、위점막손상발생솔균저우대조조（ P ＜0．05）；관찰조치료후위액pH치고우대조조（ P ＜0．01）。결론애색미랍서능유효완해장기복용NSAIDs환자상소화도증상，방치위점막손상，정체료효우우법막체정。
Objective To compared clinical effects of esomeprazole and famotidine on gastric mucosa damage induced by long-term use NSAIDs.Methods One hundred twenty-seven cases patients with long-term use NSAIDs were divided into observation group and control group.The observation group were given esomeprazole and the control group were given famotidine.The upper gastro-intestinal symptoms,gastric mucosal injury,gastric juice pH value were compared.Results Observation group incidence of upper gas-trointestinal symptoms,gastric mucosal injury were lower than that of the control group( P <0.05).Gastric juice pH was higher than that of the control group( P <0.01) .Conclusion Esomeprazole can effectively relieve upper gastrointestinal symptoms by long-term use NSAIDs,prevention and treatment of gastric mucosal injury.