CAJ | 학술논문

目的：为提高白杨素的水溶性和生物利用度，用羟丙基-β-环糊精对其进行包合，拓宽白杨素的药用途径。方法利用研磨法制备白杨素-羟丙基-β-环糊精包合物，通过粉末X射线衍射分析、差示扫描量热分析和红外光谱分析等方法对制备的白杨素-羟丙基-β-环糊精包合物进行鉴定和表征；应用紫外分光光度法对包合物的溶解度进行测定。结果白杨素与羟丙基-β-环糊精形成包合物，包合前后溶解度考察表明，形成包合物后白杨素的溶解度增加了120．7倍。结论羟丙基-β-环糊精对白杨素具有良好的增溶作用，白杨素环糊精包合物的制备方法简捷实用，达到了增加药物溶解度的目的，有助于白杨素的进一步开发利用。
목적：위제고백양소적수용성화생물이용도，용간병기-β-배호정대기진행포합，탁관백양소적약용도경。방법이용연마법제비백양소-간병기-β-배호정포합물，통과분말X사선연사분석、차시소묘량열분석화홍외광보분석등방법대제비적백양소-간병기-β-배호정포합물진행감정화표정；응용자외분광광도법대포합물적용해도진행측정。결과백양소여간병기-β-배호정형성포합물，포합전후용해도고찰표명，형성포합물후백양소적용해도증가료120．7배。결론간병기-β-배호정대백양소구유량호적증용작용，백양소배호정포합물적제비방법간첩실용，체도료증가약물용해도적목적，유조우백양소적진일보개발이용。
Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin .Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins in-clusion compound .The PXRD, DSC and IR techniques had been used to characterize the inclusion compound .Results Chrysin and hydroxypropyl-β-cyclodextrins had formed the inclusion compound , and the formation of the inclusion compound could increase solubili-ty by 120.7 times.Conclusion The inclusion compound preparation method was simple and available , which was suitable to improve the bioavailability .