CAJ | 학술논문

总结脑缺血和再灌注损伤的发生和防治机制的研究进展，展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2＋超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na＋和Ca2＋内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。
총결뇌결혈화재관주손상적발생화방치궤제적연구진전，전망미래연구추세。채용문헌귀납총결적방법진행분석。뇌결혈화재관주조성적손상여염성반응、세포내Ca2＋초재、자유기적신속증가、흥강성안기산적대량석방등인소유관。방치뇌결혈화재관주손상적궤제주요유축단결혈시간、조단곡안산수체우련적Na＋화Ca2＋내류、청제자유기、억제조망、감경염증반응、촉진신경원생장여수복등다개방면。다파점연합치료가능시방치뇌결혈화재관주손상적일개방향。
To summarize the advances in mechanisms of damage and treatments of cerebral ischemia and reperfusion and fore -casts future research directions .The existing achievements in literatures were summarized .Cerebral ischemia and reperfusion damage were related to inflammatory response , intracellular calcium overload , free radicals injury , release of excitatory amino acids and other factors.The treatments included reducing ischemia time , blocking glutamate receptors , free radical scavenging , inhibition of apoptosis , reducing inflammation , and promoting neuronal growth , etc.Multi-target treatment would be future directions in treatment of cerebral ischemia.