中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
4期
34-36
,共3页
前列地尔%造影剂肾病%预防
前列地爾%造影劑腎病%預防
전렬지이%조영제신병%예방
Alprostadil%Contrast-induced nephropathy%Prevention
目的 观察前列地尔对冠状动脉介入诊疗术患者造影剂肾病(CIN)的预防作用.方法 将215例接受冠状动脉介入诊疗术患者按随机数字表法分为治疗组(1 12例)和对照组(103例),对照组给予常规治疗,治疗组在常规治疗的基础上从术前1d开始给予前列地尔10 μg+0.9％氯化钠10ml静脉推注,每天2次,连用7～ 10d.观察两组的合并症及CIN发生情况等.结果 治疗组CIN发生率明显低于对照组[7.1％(8/112)比18.4％(19/103),P＜0.05].肾功能不全患者CIN发生率明显高于肾功能正常患者[51.6％(16/31)比6.0％(11/184),P＜0.01].糖尿病患者CIN发生率明显高于非糖尿病患者[22.1％(15/68)比8.2％(12/147),P＜ 0.01].结论 在行冠状动脉介入诊疗术前给予患者前列地尔能明显减少CIN的发生,要注意肾功能不全和糖尿病患者更易发生CIN.
目的 觀察前列地爾對冠狀動脈介入診療術患者造影劑腎病(CIN)的預防作用.方法 將215例接受冠狀動脈介入診療術患者按隨機數字錶法分為治療組(1 12例)和對照組(103例),對照組給予常規治療,治療組在常規治療的基礎上從術前1d開始給予前列地爾10 μg+0.9％氯化鈉10ml靜脈推註,每天2次,連用7～ 10d.觀察兩組的閤併癥及CIN髮生情況等.結果 治療組CIN髮生率明顯低于對照組[7.1％(8/112)比18.4％(19/103),P＜0.05].腎功能不全患者CIN髮生率明顯高于腎功能正常患者[51.6％(16/31)比6.0％(11/184),P＜0.01].糖尿病患者CIN髮生率明顯高于非糖尿病患者[22.1％(15/68)比8.2％(12/147),P＜ 0.01].結論 在行冠狀動脈介入診療術前給予患者前列地爾能明顯減少CIN的髮生,要註意腎功能不全和糖尿病患者更易髮生CIN.
목적 관찰전렬지이대관상동맥개입진료술환자조영제신병(CIN)적예방작용.방법 장215례접수관상동맥개입진료술환자안수궤수자표법분위치료조(1 12례)화대조조(103례),대조조급여상규치료,치료조재상규치료적기출상종술전1d개시급여전렬지이10 μg+0.9％록화납10ml정맥추주,매천2차,련용7～ 10d.관찰량조적합병증급CIN발생정황등.결과 치료조CIN발생솔명현저우대조조[7.1％(8/112)비18.4％(19/103),P＜0.05].신공능불전환자CIN발생솔명현고우신공능정상환자[51.6％(16/31)비6.0％(11/184),P＜0.01].당뇨병환자CIN발생솔명현고우비당뇨병환자[22.1％(15/68)비8.2％(12/147),P＜ 0.01].결론 재행관상동맥개입진료술전급여환자전렬지이능명현감소CIN적발생,요주의신공능불전화당뇨병환자경역발생CIN.
Objective To observe the preventive effect of alprostadil on contrast-induced nephropathy (CIN) in patients undergoing coronary intervention.Methods Two hundred and fifteen patients undergoing coronary intervention were divided into treatment group (112 cases) and control group (103 cases) by random digits table method.Patients in treatment group were treated routinely with addition of alprostadil (10 μ g intravenous injection every 12 h once for 7-10 days,given before surgery).Patients in control group were given routine therapy only.Complications of the two groups and CIN occurrence were observed.Results The occurrence rate of CIN in treatment group was lower than that in control group[7.1％ (8/112) vs.18.4％ (19/103),P ＜ 0.05].The occurrence rate of CIN in patients with renal insufficiency was higher than that in patients with normal renal function [51.6％ (16/31) vs.6.0％ (11/184),P ＜ 0.01].The occurrence rate of CIN in patients with diabetes was higher than that in patients without diabetes [22.1％(15/68) vs.8.2％ (12/147),P ＜ 0.01].Conclusions Alprostadil in coronary intervention before treatment can obviously reduce the incidence of CIN.CIN is more likely to occur in patients with renal insufficiency or with diabetes.
