CAJ | 학술논문

目的：探讨针刺不同效应阶段是否会引发中枢神经信号不同的传导通路。材料与方法采用非重复事件相关的实验设计模式和多元格兰杰因果有效连接度分析方法。结果研究表明针刺即时效应仅引发大脑微弱、稀疏的因果有效连接，包括经丘脑的体感上行传导通路与由额叶皮层投射到疼痛反应区的自上而下的控制通路。持续性效应阶段，仅在针刺足三里穴后会引发广泛大脑区域的更为紧密的因果连接模式。结论针刺效应可能涉及大脑网络多水平层面信息流的整合与交互。
목적：탐토침자불동효응계단시부회인발중추신경신호불동적전도통로。재료여방법채용비중복사건상관적실험설계모식화다원격란걸인과유효련접도분석방법。결과연구표명침자즉시효응부인발대뇌미약、희소적인과유효련접，포괄경구뇌적체감상행전도통로여유액협피층투사도동통반응구적자상이하적공제통로。지속성효응계단，부재침자족삼리혈후회인발엄범대뇌구역적경위긴밀적인과련접모식。결론침자효응가능섭급대뇌망락다수평층면신식류적정합여교호。
Objectives: Although accumulating evidence has demonstrated a wide range of cortico-subcortical networks underlying acute effects of acupuncture, less is understood regarding how and by what neural pathways these brain areas interact. We have recently proposed that acupuncture is a slow-acting agent and can induce speciifc patterns of dynamic CNS activities. Implicit in this evidence was the prediction that the reconifguration of brain networks underlying both acute and sustained effects of acupuncture may elucidate its overall functional speciifcity.Materials and Methods:We address the idea directly by adopting a non-repeated event-related design paradigm and multivariate Granger causality analysis (mGCA).Results:We found that brain areas were only sparsely causal connected at early acupuncture needling stage, mainly including ascending path from the thalamus as well as top-down control signals from frontal cortices to nociceptive information processing areas. As time prolonged (sustained effect), more extensive regions integrated into a dense, causally interconnected network only following acupuncture at ST36 but not nonacupoint. Additionally, this reorganization of wide brain networks seemed to be evolved from the resting state.Conclusions:These findings highlighted that the specific effect of acupuncture may involve the integration of recurrent information lfow among multi-levels of brain networks.