磁共振成像
磁共振成像
자공진성상
CHINESE JOURNAL OF MAGNETIC RESONANCE IMAGING
2014年
6期
416-422
,共7页
方继良%洪洋%范洋洋%刘军%马云遥%徐春华%王鸿红%马迎歌%王小玲%刘志顺%朱兵%孔健%荣培晶
方繼良%洪洋%範洋洋%劉軍%馬雲遙%徐春華%王鴻紅%馬迎歌%王小玲%劉誌順%硃兵%孔健%榮培晶
방계량%홍양%범양양%류군%마운요%서춘화%왕홍홍%마영가%왕소령%류지순%주병%공건%영배정
电针%耳甲部%经皮迷走神经刺激%功能磁共振成像%脑激活%脑负激活
電針%耳甲部%經皮迷走神經刺激%功能磁共振成像%腦激活%腦負激活
전침%이갑부%경피미주신경자격%공능자공진성상%뇌격활%뇌부격활
Electronical acupuncture%Auricular concha region%Transcutaneous vagus nerve electronical stimulation%Functional magnetic resonance imaging%Brain activation%Negative brain deactivation
目的：探讨耳甲迷走神经刺激术的脑通路，为耳迷走神经刺激调制孤束核-边缘叶脑网络假说提供证据。材料与方法随机录用16名健康志愿者，参加经皮电刺激右耳甲部迷走神经分布区(tVNS)，以同侧上耳舟部刺激为对照，记录刺激的耳部感觉，观察全脑6 min扫描的Bold-fMRI信号变化，分析脑功能激活特点，应用SPM8处理fMRI数据。结果两组电流、感觉频率及强度未见明显区别。经皮电刺激耳甲部tVNS正常人激发了左侧孤束核及边缘叶脑区广泛而较强的负激活效应，局限性激活位于体感区及岛叶等，而对照部产生了右侧三叉神经核等脑干核团负激活及脑部体感区明显的激活现象。结论经皮电刺激迷走神经产生了孤束核-边缘叶脑网络的调制效应，为经皮电刺激耳甲部迷走神经治疗抑郁症等脑中枢机制打下基础。
目的：探討耳甲迷走神經刺激術的腦通路，為耳迷走神經刺激調製孤束覈-邊緣葉腦網絡假說提供證據。材料與方法隨機錄用16名健康誌願者，參加經皮電刺激右耳甲部迷走神經分佈區(tVNS)，以同側上耳舟部刺激為對照，記錄刺激的耳部感覺，觀察全腦6 min掃描的Bold-fMRI信號變化，分析腦功能激活特點，應用SPM8處理fMRI數據。結果兩組電流、感覺頻率及彊度未見明顯區彆。經皮電刺激耳甲部tVNS正常人激髮瞭左側孤束覈及邊緣葉腦區廣汎而較彊的負激活效應，跼限性激活位于體感區及島葉等，而對照部產生瞭右側三扠神經覈等腦榦覈糰負激活及腦部體感區明顯的激活現象。結論經皮電刺激迷走神經產生瞭孤束覈-邊緣葉腦網絡的調製效應，為經皮電刺激耳甲部迷走神經治療抑鬱癥等腦中樞機製打下基礎。
목적：탐토이갑미주신경자격술적뇌통로，위이미주신경자격조제고속핵-변연협뇌망락가설제공증거。재료여방법수궤록용16명건강지원자，삼가경피전자격우이갑부미주신경분포구(tVNS)，이동측상이주부자격위대조，기록자격적이부감각，관찰전뇌6 min소묘적Bold-fMRI신호변화，분석뇌공능격활특점，응용SPM8처리fMRI수거。결과량조전류、감각빈솔급강도미견명현구별。경피전자격이갑부tVNS정상인격발료좌측고속핵급변연협뇌구엄범이교강적부격활효응，국한성격활위우체감구급도협등，이대조부산생료우측삼차신경핵등뇌간핵단부격활급뇌부체감구명현적격활현상。결론경피전자격미주신경산생료고속핵-변연협뇌망락적조제효응，위경피전자격이갑부미주신경치료억욱증등뇌중추궤제타하기출。
Objectives: To investigate the BOLD fMRI response to transcutaneous vagus nerve electronical stimulation (tVNS) at auricular concha region (ACR) on the healthy. It is hypothesized that tVNS modulates the network of nucleus of tract solitary-limbic system. Materials and Methods: Sixteen healthy subjects (18-27 y) were enrolled in the fMRI study. The fMRI was conducted during tVNS on ACR controlled with sham-tVNS on the superior scapha respectively. Subjects’ sensations were recorded after every fMRI scan. Each functional scan lasted 6 minutes. SPM8 was employed for the fMRI data processing.Results: The current, and the sensations’ frequency and strength of electronical stimulation were similar between two groups. The tVNS induced the predominant deactivation in the left nucleus of tract solitary and brain regions involving in limbic function, and the activation was limited in left SII, left anterior insula, etc. However, the sham tVNS showed the deactivation in the areas of right nucleus of trigeminal nerve, the obvious activation in the somato-sensory areas. Conclusions: tVNS modulated the network of nucleus of tract solitary-limbic system. It would provide the basis of therapeutic mechanism of tVNS treating Depression.
