中国民康医学
中國民康醫學
중국민강의학
MEDICAL JOURNAL OF CHINSEE PEOPLE HEALTH
2014年
21期
8-10
,共3页
丹参多酚酸盐%不稳定性心绞痛%窦性心率震荡%高敏C反应蛋白%肌酸激酶同功酶
丹參多酚痠鹽%不穩定性心絞痛%竇性心率震盪%高敏C反應蛋白%肌痠激酶同功酶
단삼다분산염%불은정성심교통%두성심솔진탕%고민C반응단백%기산격매동공매
Salvianolate%Unstable angina%Heart rate turbulence%High sensitive C-reactive protein%Creatine kinase isoenzyme
目的：：探讨注射用丹参多酚酸盐对不稳定性心绞痛患者窦性心率震荡及血清心肌损伤指标的影响。方法：采用随机数字表法将患者分为对照组、观察组。对照组患者进行常规西药治疗，观察组患者除进行常规西药治疗外，还加用丹参多酚酸盐治疗。患者于入组时及治疗14d后分别进行心电图窦性心率震荡(HRT)、高敏C反应蛋白(hs-CRP)及肌酸激酶同功酶(CK-MB)检测，并比较治疗14d后患者的心电图及临床疗效。结果：两组患者治疗后震荡初始(TO)值均显著降低(P<0.05)，震荡斜率(TS)值均显著增加(P<0.05)；治疗后观察组患者TO、TS值变化更加明显(P<0.01)。两组患者治疗后血清hs-CRP、CK-MB水平均显著降低，较治疗前均有明显差异，有显著统计学意义(P<0.01)，血清hs-CRP、CK-MB水平治疗后观察组降低更加明显(P<0.01)。治疗14d后两组患者心电图改变、临床症状缓解情况，观察组显著好于对照组(P<0.05)。结论：注射用丹参多酚酸盐可明显改善不稳定性心绞痛患者窦性心率震荡，降低血清hs-CRP、CK-MB水平。
目的：：探討註射用丹參多酚痠鹽對不穩定性心絞痛患者竇性心率震盪及血清心肌損傷指標的影響。方法：採用隨機數字錶法將患者分為對照組、觀察組。對照組患者進行常規西藥治療，觀察組患者除進行常規西藥治療外，還加用丹參多酚痠鹽治療。患者于入組時及治療14d後分彆進行心電圖竇性心率震盪(HRT)、高敏C反應蛋白(hs-CRP)及肌痠激酶同功酶(CK-MB)檢測，併比較治療14d後患者的心電圖及臨床療效。結果：兩組患者治療後震盪初始(TO)值均顯著降低(P<0.05)，震盪斜率(TS)值均顯著增加(P<0.05)；治療後觀察組患者TO、TS值變化更加明顯(P<0.01)。兩組患者治療後血清hs-CRP、CK-MB水平均顯著降低，較治療前均有明顯差異，有顯著統計學意義(P<0.01)，血清hs-CRP、CK-MB水平治療後觀察組降低更加明顯(P<0.01)。治療14d後兩組患者心電圖改變、臨床癥狀緩解情況，觀察組顯著好于對照組(P<0.05)。結論：註射用丹參多酚痠鹽可明顯改善不穩定性心絞痛患者竇性心率震盪，降低血清hs-CRP、CK-MB水平。
목적：：탐토주사용단삼다분산염대불은정성심교통환자두성심솔진탕급혈청심기손상지표적영향。방법：채용수궤수자표법장환자분위대조조、관찰조。대조조환자진행상규서약치료，관찰조환자제진행상규서약치료외，환가용단삼다분산염치료。환자우입조시급치료14d후분별진행심전도두성심솔진탕(HRT)、고민C반응단백(hs-CRP)급기산격매동공매(CK-MB)검측，병비교치료14d후환자적심전도급림상료효。결과：량조환자치료후진탕초시(TO)치균현저강저(P<0.05)，진탕사솔(TS)치균현저증가(P<0.05)；치료후관찰조환자TO、TS치변화경가명현(P<0.01)。량조환자치료후혈청hs-CRP、CK-MB수평균현저강저，교치료전균유명현차이，유현저통계학의의(P<0.01)，혈청hs-CRP、CK-MB수평치료후관찰조강저경가명현(P<0.01)。치료14d후량조환자심전도개변、림상증상완해정황，관찰조현저호우대조조(P<0.05)。결론：주사용단삼다분산염가명현개선불은정성심교통환자두성심솔진탕，강저혈청hs-CRP、CK-MB수평。
Objective:To explore effects of Salvianolate on heart rate turbulence and myocardial injury serum index in patients with unstable angina. Methods:The patients were divided into observation group (42 cases) and control group (40 cases) by random number table method. Western medicine therapy was conducted for control group, while conventional western medicine therapy was also conducted for observation group, complemented by Salvianolate. At the beginning of group division and 14 days after the therapy, heart rate turbulence ( HRT) in electrocardiogram, high sensitive C-reactive protein ( hs-CRP) and creatine kinase isoenzyme ( CK-MB) were detected. Electrocardiogram and clinical effectiveness were compared after 14-day therapy. Results:After the therapy, the turbu-lence onset (TO) values of the two groups were reduced dramatically (P<0. 05), while turbulence slope (TS) values of the two groups increased significantly (P<0. 05). After the therapy, the differences of observation group in TO and TS values were more signif-icant (P<0. 01) After the therapy, the levels of hs-CRP and CK-MB of the two groups decreased significantly, and the differences before and after the therapy were statistically significant (P<0. 01);moreover, the decreases in observation were more significant (P<0. 01). After the 14-day therapy, the improvements in electrocardiogram and clinical symptoms of observation group were much better than those of control group (P<0. 05). Conclusions:Salvianolate for injection for the patients with instable angina can improve HRT index more effectively, and reduce the levels of hs-CRP and CK-MB.
