上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
21期
71-73,77
,共4页
FK506%树脂%吸附
FK506%樹脂%吸附
FK506%수지%흡부
FK506%resin%adsorption
目的：研究并优化FK506提取工艺。方法：通过几种大孔吸附树脂的吸附容量及分离能力比较实验，筛选到一种吸附容量高又有分离能力的树脂；通过吸附等温线及柱分离实验，确定最佳吸附浓度、上样及洗脱流速等工艺参数。结果：FK506提取液通过HZ816树脂吸附分离掉杂质，中间体湿粉含量达到60.1%（折干含量81.3%），吸附分离总收率达87.1%。结论：HZ816树脂可有效吸附分离FK506。
目的：研究併優化FK506提取工藝。方法：通過幾種大孔吸附樹脂的吸附容量及分離能力比較實驗，篩選到一種吸附容量高又有分離能力的樹脂；通過吸附等溫線及柱分離實驗，確定最佳吸附濃度、上樣及洗脫流速等工藝參數。結果：FK506提取液通過HZ816樹脂吸附分離掉雜質，中間體濕粉含量達到60.1%（摺榦含量81.3%），吸附分離總收率達87.1%。結論：HZ816樹脂可有效吸附分離FK506。
목적：연구병우화FK506제취공예。방법：통과궤충대공흡부수지적흡부용량급분리능력비교실험，사선도일충흡부용량고우유분리능력적수지；통과흡부등온선급주분리실험，학정최가흡부농도、상양급세탈류속등공예삼수。결과：FK506제취액통과HZ816수지흡부분리도잡질，중간체습분함량체도60.1%（절간함량81.3%），흡부분리총수솔체87.1%。결론：HZ816수지가유효흡부분리FK506。
Objective:To optimize the technology for the isolation and puriifcation of FK506. Methods:A macroporous absorption resin with high adsorption and separation capability was selected through experiments based on its adsorption capability and separation ability. Process parameters such as the volume and the optimum adsorption concentration of sample and the elution lfow were determined via adsorption isotherm and column separation experiments. Results:The content of the wet powder of FK506 intermediate was 60.1%(81.3%on dry content) through the adsorption of impurities from FK506 extracts by resin HZ816 with total yield of 87.1%. Conclusion:FK506 can be effectively separated and puriifed by macroporous resin HZ816.
