CAJ | 학술논문

目的：探讨中国常州地区人群白介素-10（IL-10）基因1082G/A多态性与不稳定型心绞痛(UAP)发病的关系。方法：招募了299例研究对象并分成UAP组（n=146）和对照组（n=153），经测序鉴定IL-10基因1082G/A多态性，并检测血糖和血脂等生化指标。结果：IL-10基因1082G/A在UAP组和对照组中均存在GG、AG和AA这3种基因型；3种基因型分布频率、等位基因分布频率与对照组相比均无统计学差异；调整对多个危险因素行多元logistic回归分析，示IL-10基因1082G/A 3种基因型与UAP的发病仍无相关性。结论：IL-10基因1082G/A多态性与中国常州地区人群UAP的发病无相关性。
목적：탐토중국상주지구인군백개소-10（IL-10）기인1082G/A다태성여불은정형심교통(UAP)발병적관계。방법：초모료299례연구대상병분성UAP조（n=146）화대조조（n=153），경측서감정IL-10기인1082G/A다태성，병검측혈당화혈지등생화지표。결과：IL-10기인1082G/A재UAP조화대조조중균존재GG、AG화AA저3충기인형；3충기인형분포빈솔、등위기인분포빈솔여대조조상비균무통계학차이；조정대다개위험인소행다원logistic회귀분석，시IL-10기인1082G/A 3충기인형여UAP적발병잉무상관성。결론：IL-10기인1082G/A다태성여중국상주지구인군UAP적발병무상관성。
Objective:To study the association between the polymorphism of interleukin-10(IL-10)gene 1082G/A and the incidence of unstable angina pectoris (UAP) in the Chinese Han population of Changzhou region. Methods:Two hundred and ninety-nine subjects were recruited and divided into a UAP group (n=146) and a control group (n=153), who were free from coronary artery disease. The polymorphism of IL-10 gene 1082G/A from those subjects was identiifed by sequencing and meanwhile biochemical indicators such as blood sugar and blood lipid were determined. Results:There were three kinds of genotypes including GG, AG and AA in two groups and the distribution frequencies of their genotypes and alleles had no statistical difference and the logistic regression analysis of multivariate risk factors such as smoking, blood pressure, blood sugar, TG, TC, LDL, HDL showed that genotypes and the incidence of UAP had no correlation either. Conclusion:The polymorphism of IL-10 gene was no associated with UAP in the Chinese Han population of Changzhou region.