CAJ | 학술논문

目的：探讨丹红注射液配合调脂治疗对冠心病心绞痛患者血管内皮功能的影响。方法：选取2010年10月至2013年12月期间我院确诊治疗的冠心病心绞痛患者106例，依据随机分配原则分为观察组和对照组各53例，两组患者均在冠心病基础治疗上，对照组患者给予调脂治疗，观察组患者给予丹红注射液配合调脂治疗，对比分析两组患者血浆中血清总胆固醇（TC）水平、甘油三脂（TG）水平、左心室射血（LVEF）分数和血管肱动脉内皮依赖性舒张功能（FMD）情况以及治疗后不良事件发生情况。结果：观察组患者治疗后血浆中TC、TG水平明显低于对照组，前者LVEF分数明显高于后者（P＜0.05）；观察组患者治疗后FMD功能分数明显高于对照组（P＜0.01）；两组患者治疗后不良事件发生率无显著差异（P＜0.05）。结论：丹红注射液配合调脂治疗可有效降低冠心病心绞痛患者血管中血脂，提高患者血管内皮功能，促进患者心脏正常功能的恢复，且无增加心血管不良事件发生的风险，值得临床作进一步推广。
목적：탐토단홍주사액배합조지치료대관심병심교통환자혈관내피공능적영향。방법：선취2010년10월지2013년12월기간아원학진치료적관심병심교통환자106례，의거수궤분배원칙분위관찰조화대조조각53례，량조환자균재관심병기출치료상，대조조환자급여조지치료，관찰조환자급여단홍주사액배합조지치료，대비분석량조환자혈장중혈청총담고순（TC）수평、감유삼지（TG）수평、좌심실사혈（LVEF）분수화혈관굉동맥내피의뢰성서장공능（FMD）정황이급치료후불량사건발생정황。결과：관찰조환자치료후혈장중TC、TG수평명현저우대조조，전자LVEF분수명현고우후자（P＜0.05）；관찰조환자치료후FMD공능분수명현고우대조조（P＜0.01）；량조환자치료후불량사건발생솔무현저차이（P＜0.05）。결론：단홍주사액배합조지치료가유효강저관심병심교통환자혈관중혈지，제고환자혈관내피공능，촉진환자심장정상공능적회복，차무증가심혈관불량사건발생적풍험，치득림상작진일보추엄。
Objective:To investigate the effect of Danhong injection combined with lipid-lowering therapy on the vascular endothelial function in patients with angina pectoris. Methods: One hundred and six cases of patients with angina pectoris diagnosed and treated in our hospital from October 2010 to December 2013 were randomly divided into an observation group and a control group with 53 cases each. Danhong injection combined with lipid-lowering therapy was given in the observation group while only lipid-lowering therapy in the control group on the basis of the basic treatment of coronary heart disease. Total cholesterol (TC) level, triglycerides (TG) level, left ventricular ejection fraction (LVEF), lfow-mediated dilation (FMD) of the brachial artery and adverse events occurring after the treatment were compared between two groups. Results:The TC and TG levels were signiifcantly lower in the observation group than in the control group while the LVEF score (P<0.05) and FMD score were signiifcantly higher (P<0.01) in the observation group than in the control group. The incidence of adverse events in two groups had no signiifcant differences (P<0.05). Conclusion:This combination therapy can effectively reduce blood lipids, improve vascular endothelial function and promote the recovery of normal heart function without increasing the risk of cardiovascular adverse events, which is worthy of clinical use.