CAJ | 학술논문

目的：探讨肺癌患者血清肿瘤标志物癌胚抗原（ CEA）、鳞状细胞癌抗原（ SCC-Ag）、细胞角蛋白19片段（ CYFRA21-1）和神经元特异性烯醇化酶（ NSE）与三种肺癌病理分型间的相关性及其临床意义。方法通过统计学方法对56例确诊肺癌患者治疗前的血清癌胚抗原（ CEA）、鳞状细胞癌抗原（ SCC-Ag）、细胞角蛋白19片段（ CYFRA21-1）和神经元特异性烯醇化酶（ NSE）阳性率结合病理分型进行分析。结果癌胚抗原（ CEA）在腺癌组阳性率为65骀．00％，明显高于鳞癌和小细胞肺癌组（ P ＜0．01）；鳞状细胞癌抗原（SCC-Ag）、细胞角蛋白19片段（CYFRA21-1）在鳞癌组阳性率分别为47．37％、57．89％，明显高于腺癌组和小细胞肺癌组（ P ＜0．01）；神经元特异性烯醇化酶（ NSE）在小细胞癌组阳性率为76．47％，明显高于鳞癌和腺癌组（ P ＜0．01）。结论癌胚抗原（ CEA ）、鳞状细胞癌抗原（ SCC-Ag）和细胞角蛋白19片段（ CYFRA21-1）是较好的非小细胞肺癌肿瘤标记物。癌胚抗原（ CEA）与腺癌之间有明显相关性。鳞状细胞癌抗原（SCC-Ag）和细胞角蛋白19片段（CYFRA21-1）与鳞癌之间有明显相关性。神经元特异性烯醇化酶（ NSE）与小细胞癌有明显相关性。对不宜手术的肺癌患者，四种肿瘤标记物对患者病理分型有较好的提示作用，并能对临床的针对性治疗提供一定的帮助。
목적：탐토폐암환자혈청종류표지물암배항원（ CEA）、린상세포암항원（ SCC-Ag）、세포각단백19편단（ CYFRA21-1）화신경원특이성희순화매（ NSE）여삼충폐암병리분형간적상관성급기림상의의。방법통과통계학방법대56례학진폐암환자치료전적혈청암배항원（ CEA）、린상세포암항원（ SCC-Ag）、세포각단백19편단（ CYFRA21-1）화신경원특이성희순화매（ NSE）양성솔결합병리분형진행분석。결과암배항원（ CEA）재선암조양성솔위65태．00％，명현고우린암화소세포폐암조（ P ＜0．01）；린상세포암항원（SCC-Ag）、세포각단백19편단（CYFRA21-1）재린암조양성솔분별위47．37％、57．89％，명현고우선암조화소세포폐암조（ P ＜0．01）；신경원특이성희순화매（ NSE）재소세포암조양성솔위76．47％，명현고우린암화선암조（ P ＜0．01）。결론암배항원（ CEA ）、린상세포암항원（ SCC-Ag）화세포각단백19편단（ CYFRA21-1）시교호적비소세포폐암종류표기물。암배항원（ CEA）여선암지간유명현상관성。린상세포암항원（SCC-Ag）화세포각단백19편단（CYFRA21-1）여린암지간유명현상관성。신경원특이성희순화매（ NSE）여소세포암유명현상관성。대불의수술적폐암환자，사충종류표기물대환자병리분형유교호적제시작용，병능대림상적침대성치료제공일정적방조。
Objective To investigate the correlation between four kinds of serum tumor markers including CEA, SCC-Ag,CYFRA21-1,NSE and three kinds of different pathological types of lung cancer.Methods The positive rates of CEA,SCC-Ag, CYFRA21-1, NSE in serum of 56 patients with lung cancer before treatment were statistically analyzed, combined with different pathological types.Results The positive rate of CEA in lung adenocarcinoma group was 65%,which was significantly higher than that in squamous cell carcinoma group and small cell lung cancer group ( P <0.01).The posi-tive rate of SCC-Ag and CYFRA21-1 in squamous cell carcinoma group was 47.37% and 57.89%,respectively,which was significantly higher than that in lung adenocarcinoma group and small cell lung cancer group ( P <0.01).The positive rate of NSE in small cell lung cancer group was 76.47%,which was significantly higher than that in lung adenocarcinoma group and squamous cell carcinoma group ( P <0.01 ) .Conclusion The CEA,SCC-Ag and CYFRA21-1 are sensitive tumor markers for non-small cell lung cancer.CEA is closely related with lung adenocarcinoma.SCC-Ag and CYFRA21-1 are closely correlated to squamous cell carcinoma.NSE is closely related with small cell lung cancer.The four kinds of tumor markers are helpful for pathological typing of lung cancers and for clinical treatment,especially for the patients who are inoperable.