CAJ | 학술논문

目的：比较慢性阻塞性肺疾病急性加重（ AECOPD ）患者综合治疗前后血浆 N 端脑利钠肽前体（ NT-proBNP）水平的变化并探讨其临床应用价值。方法30例满足条件的AECOPD患者，分别检测入院时及24 h治疗后患者血浆NT-proBNP水平，急性生理学及慢性健康状况评分Ⅱ（APACHEⅡ评分）及肺动脉压（PAP）水平。结果入院时患者NT-proBNP水平与APACHEⅡ评分及PAP值呈正相关（分别为r ＝0厖．763和r＝0．888，均P ＜00．1），24 h治疗后患者总体NT-proBNP水平、APACHE Ⅱ评分及PAP值相比治疗前明显下降，差异有统计学意义（ P ＜0．05）。治疗后患者NT-proBNP水平与APACHE Ⅱ评分及PAP 值仍呈正相关（ r值分别为0．609和0．821， P ＜0．01）。结论血浆NT-proBNP水平与APACHEⅡ评分及PAP值具有良好的正相关性，可用于AECOPD患者病情严重程度评估。
목적：비교만성조새성폐질병급성가중（ AECOPD ）환자종합치료전후혈장 N 단뇌리납태전체（ NT-proBNP）수평적변화병탐토기림상응용개치。방법30례만족조건적AECOPD환자，분별검측입원시급24 h치료후환자혈장NT-proBNP수평，급성생이학급만성건강상황평분Ⅱ（APACHEⅡ평분）급폐동맥압（PAP）수평。결과입원시환자NT-proBNP수평여APACHEⅡ평분급PAP치정정상관（분별위r ＝0방．763화r＝0．888，균P ＜00．1），24 h치료후환자총체NT-proBNP수평、APACHE Ⅱ평분급PAP치상비치료전명현하강，차이유통계학의의（ P ＜0．05）。치료후환자NT-proBNP수평여APACHE Ⅱ평분급PAP 치잉정정상관（ r치분별위0．609화0．821， P ＜0．01）。결론혈장NT-proBNP수평여APACHEⅡ평분급PAP치구유량호적정상관성，가용우AECOPD환자병정엄중정도평고。
Obej ctive To investigate the clinical significance of N-terminal pro-brain natriuretic peptide ( NT-proBNP) levels in patients with acute exacerbation chronic obstructive pulmonary disease ( AECOPD) M.ethods Thirty patients with AECOPD were enrolled in the study .The plasma levels of NTp-roBNP,APACHEⅡscores and pulmonary artery pressures ( PAP) were measured before treatment and 24 hours after treatment for all the patients .Results The NT -proBNP levels were positively correlated to APACHEⅡscores ( r =0.763, P <0.01) and to PAP value ( r =0.888, P <0.01) in patients with AECOPD before treatment.However after 24-hour treatment,NT-proBNP levels,APACHE Ⅱ scores as well as PAP value were significantly decreased,as compared with those before treatment ( P <0.05).After treatment NT-proBNP levels were still positively correlated to APACHE Ⅱ scores (r =0.609, P <0.01) and to PAP value ( r =0.821, P <0.01).Conclusion There are favourable positive correlations between NT -proBNP levels and APACHE Ⅱscores as well as PAP value,which can reflect the severity of pathogenetic condition of patients with AECOPD.