CAJ | 학술논문

目的：观察预混门冬胰岛素50与预混人胰岛素50R 在2型糖尿病患者中的临床疗效及安全性。方法选取收治的2型糖尿病患者76例，随机分为预混门冬胰岛素50组和预混人胰岛素50R 组各38例，采用2次皮下注射方案，药物剂量依据血糖调整，为期12周，观察2组患者空腹血糖、餐后2h 血糖、糖化血红蛋白、低血糖事件、每日胰岛素用量。结果与预混人胰岛素50R 组相比，预混门冬胰岛素50组治疗后餐后2h 血糖降低明显（P ＜0．05），空腹血糖、糖化血红蛋白下降差异无统计学意义（P ＞0．05），低血糖发生率明显降低、胰岛素应用剂量减少，差异有统计学意义（P ＜0．05）。结论预混门冬胰岛素50在提高患者的治疗效果和依从性的同时，减少了低血糖发生，适于临床推广应用。
목적：관찰예혼문동이도소50여예혼인이도소50R 재2형당뇨병환자중적림상료효급안전성。방법선취수치적2형당뇨병환자76례，수궤분위예혼문동이도소50조화예혼인이도소50R 조각38례，채용2차피하주사방안，약물제량의거혈당조정，위기12주，관찰2조환자공복혈당、찬후2h 혈당、당화혈홍단백、저혈당사건、매일이도소용량。결과여예혼인이도소50R 조상비，예혼문동이도소50조치료후찬후2h 혈당강저명현（P ＜0．05），공복혈당、당화혈홍단백하강차이무통계학의의（P ＞0．05），저혈당발생솔명현강저、이도소응용제량감소，차이유통계학의의（P ＜0．05）。결론예혼문동이도소50재제고환자적치료효과화의종성적동시，감소료저혈당발생，괄우림상추엄응용。
Objective To compare the safety and efficacy of biphasic insulin aspart 50 (BIAsp 50 )and premixed human insulin 50 (BHI 50 )on type 2 diabetes mellitus (T2DM) patients.Methods A total of 76 T2DM patients were randomly divided into BIAsp 50 group(38 cases)and BHI 50 group(38 cases).The fasting blood glucose (FBG),2-hour postprandial blood glucose (2hPG)and glycated hemoglobin(HbA1 c)after 12 weeks′insulin aspart 50 treatment, the insulin dosage and hypoglycemic episodes were compared.Results After 12 weeks′treatment,the decrease of 2hPG in BIAsp 50 group was more than that in BHI 50 group (P <0.05).Besides,in BIAsp 50 group,the incidence of hypoglycemic episodes was reduced,the insulin dosage was smaller,both showing significant differences (P <0.05).Conclusion BIAsp 50 could improve treatment efficiency and patients′ compliance.It is economic and suitable for widely clinical application.