CAJ | 학술논문

肠道病毒71型（ EV71）是疱疹性咽峡炎和手足口病最重要的诱因之一，并能引发严重的中枢神经系统并发症，伴随着肺水肿的脑干脑炎可致死。细胞因子作为先天免疫的一部分，有利于抗病毒和Th1免疫反应的进行。细胞因子和炎症趋化因子在EV71脑干脑炎发病中起重要作用。在EV71肺水肿发病过程中，中枢神经系统和全身炎症应答对感染扮演重要但明显不同的角色。静脉滴注免疫球蛋白和磷酸二酯酶抑制剂，对EV71自主神经系统失调和肺水肿患者可以起到调节炎症、降低交感神经过度兴奋和提高存活率的作用。
장도병독71형（ EV71）시포진성인협염화수족구병최중요적유인지일，병능인발엄중적중추신경계통병발증，반수착폐수종적뇌간뇌염가치사。세포인자작위선천면역적일부분，유리우항병독화Th1면역반응적진행。세포인자화염증추화인자재EV71뇌간뇌염발병중기중요작용。재EV71폐수종발병과정중，중추신경계통화전신염증응답대감염분연중요단명현불동적각색。정맥적주면역구단백화린산이지매억제제，대EV71자주신경계통실조화폐수종환자가이기도조절염증、강저교감신경과도흥강화제고존활솔적작용。
Enterovirus 71 is one of the trigger factors for herpangina and hand -foot-and-mouth disease , which causes severe central nervous system complication with lethiferous brainstem encephalitis of pneumonedema . As a part of innate immunity cytokines support the antiviral and immune response to Th 1.Cytokines and chemo-kines play an important role in the pathogenesis of EV 71 brainstem encephalitis .It is obviously that the central nervous system and systemic inflammatory response play different roles in the disease progression of pneu -monedema.For patients, who suffered from EV71 autonomic nervous systems disorders and pneumonedema , intra-venous infusion of immunoglobulin and phoshodiesterase may serve to regulate inflammation , reduce sympathetic ex-cessive stimulation and improve the survival rate .