CAJ | 학술논문

观察发现，209例直肠腺癌中有112例发生了肿瘤出芽，出芽率为53；．59％。肿瘤出芽的发生率与直肠腺癌的淋巴结转移、淋巴管侵润、血管侵润、神经侵润和TNM分期明显相关（ P＜0．01），与肿瘤的浸润深度也有关（P＜0．05），但与肿瘤的分化程度无关（P＞0．05）。这表明肿瘤出芽是提示直肠腺癌侵袭性生长的形态学特征，有肿瘤出芽现象提示患者可能预后较差。
관찰발현，209례직장선암중유112례발생료종류출아，출아솔위53；．59％。종류출아적발생솔여직장선암적림파결전이、림파관침윤、혈관침윤、신경침윤화TNM분기명현상관（ P＜0．01），여종류적침윤심도야유관（P＜0．05），단여종류적분화정도무관（P＞0．05）。저표명종류출아시제시직장선암침습성생장적형태학특정，유종류출아현상제시환자가능예후교차。
Objective:To study the clinical pathologic significance of tumor budding in rectum adenocarcinoma . Methods:The tumor budding of 209 cases of rectum adenocarcinoma were detected by HE staining .Results:Tumor budding were found in 112 cases of rectum adenocarcinoma ( 53 .59%) .The incident of tumor budding in rectum adenocarcinoma had a significant correlation (P <0.01) with lymph node metastasis, lymphatic invasion, vascular invasion , nerve invasion , and TNM stages .Also it had a correlation with tumor infiltration depth ( P <0 . 05).But it didn't relate to its differentiation (P >0.05).Conclusion:Tumor budding was a potential pathologi-cal marker suggesting aggressive of rectum adenocarcinoma and it will have a poor prognosis for patients with tumor budding .