CAJ | 학술논문

目的：探讨血脂联合子宫动脉血流检测对子痫前期诊断的预测价值。方法回顾性分析在河北医科大学第四医院规律进行产前检查并分娩的子痫前期孕妇200例和健康孕妇600例资料，比较健康组孕妇与子痫前期组孕妇在孕早、中、晚期的血脂水平；随机选取588例在河北医科大学第四医院定期行产前检查并住院分娩的孕妇，对所有孕妇于孕早期进行血脂检测并于孕中期进行子宫动脉血流检测，将三酰甘油水平正常及子宫动脉血流正常的分为 A 组，孕早期三酰甘油水平升高及孕中期子宫动脉血流均正常的孕妇分为 B 组，将孕早期三酰甘油水平正常及孕中期子宫动脉血流增高的孕妇分为 C 组，三酰甘油及子宫动脉血流同时增高的孕妇分为 D 组，比较4组孕妇子痫前期发病率。结果子痫前期组孕妇孕早期三酰甘油明显高于健康组，差异有统计学意义（P ＜0．05），孕中期、晚期子痫前期组三酰甘油、胆固醇、低密度脂蛋白水平均明显高于健康组（P ＜0．05）；D 组子痫前期发病率明显高于其他3组（P ＜0．05）。结论子痫前期患者存在血脂代谢异常，尤其是三酰甘油水平于孕早期即明显升高并持续高水平状态；血脂联合子宫动脉血流检测对子痫前期发病有较高的预测价值。
목적：탐토혈지연합자궁동맥혈류검측대자간전기진단적예측개치。방법회고성분석재하북의과대학제사의원규률진행산전검사병분면적자간전기잉부200례화건강잉부600례자료，비교건강조잉부여자간전기조잉부재잉조、중、만기적혈지수평；수궤선취588례재하북의과대학제사의원정기행산전검사병주원분면적잉부，대소유잉부우잉조기진행혈지검측병우잉중기진행자궁동맥혈류검측，장삼선감유수평정상급자궁동맥혈류정상적분위 A 조，잉조기삼선감유수평승고급잉중기자궁동맥혈류균정상적잉부분위 B 조，장잉조기삼선감유수평정상급잉중기자궁동맥혈류증고적잉부분위 C 조，삼선감유급자궁동맥혈류동시증고적잉부분위 D 조，비교4조잉부자간전기발병솔。결과자간전기조잉부잉조기삼선감유명현고우건강조，차이유통계학의의（P ＜0．05），잉중기、만기자간전기조삼선감유、담고순、저밀도지단백수평균명현고우건강조（P ＜0．05）；D 조자간전기발병솔명현고우기타3조（P ＜0．05）。결론자간전기환자존재혈지대사이상，우기시삼선감유수평우잉조기즉명현승고병지속고수평상태；혈지연합자궁동맥혈류검측대자간전기발병유교고적예측개치。
Objective To investigate the effect of lipid combined with uterine artery blood flow detection in diagnosis of preeclampsia.Methods Retrospective analysis was made on 200 preeclampsia women and 600 normal pregnant women who took prenatal tests in the Fourth Hospital of Hebei Medical University.The lipid levels during the first,second and third trimester were compared between normal and preeclampsia women.A total of 588 pregnant women were randomly selected,all women were detected the lipid level during first trimester and uterine artery blood flow during second trimester.The triglyceride level and uterine artery blood flow were all normal in group A.The triglyceride level was high but uterine artery blood flow was normal in group B.The uterine artery blood flow was high but the triglyceride level was normal in group C. The triglyceride level and uterine artery blood flow were all high in group D.The incidence of preeclampsia for the four groups were compared.Results For preeclampsia women,triglyceride during first trimester was significantly higher than normal pregnant women (P <0.05);During second and third trimester,triglyceride,cholesterol and low density lipoprotein were much higher (P <0.05).The incidence of preeclampsia for group D was significantly higher than other three groups (P < 0.05 ).Conclusion Preeclampsia women had metabolic abnormalities of lipid, especially triglyceride level was high from first trimester and continued high state.Lipid combined with uterine artery blood flow detection would have higher predictive value in diagnosis of preeclampsia.