CAJ | 학술논문

目的：通过检测急性冠脉综合征（ACS）患者体内晚期糖基化终产物（AGEs）的水平，以探讨氧化应激与冠状动脉粥样硬化的关系，以及其对预后的影响。方法入选72例急性心肌梗死（AMI）、53例不稳定性心绞痛（UA）及27例非冠心病（non-CAD）患者，分别采集静脉血标本，检测AGEs浓度，并记录6月内所有患者的病情转归情况。结果与非冠心病组对应各时间点AGEs浓度比较，AMI择期PCI组、AMI急诊PCI组及UA组均有明显升高（P<0.05）。同时发现ACS患者AGEs水平高者预后差，低者预后良好。结论 ACS患者血清AGEs浓度显著升高，AGEs是反映体内氧化应激水平较好的血清学指标，并且与病情的严重程度呈正相关，对病情转归有一定预测价值。
목적：통과검측급성관맥종합정（ACS）환자체내만기당기화종산물（AGEs）적수평，이탐토양화응격여관상동맥죽양경화적관계，이급기대예후적영향。방법입선72례급성심기경사（AMI）、53례불은정성심교통（UA）급27례비관심병（non-CAD）환자，분별채집정맥혈표본，검측AGEs농도，병기록6월내소유환자적병정전귀정황。결과여비관심병조대응각시간점AGEs농도비교，AMI택기PCI조、AMI급진PCI조급UA조균유명현승고（P<0.05）。동시발현ACS환자AGEs수평고자예후차，저자예후량호。결론 ACS환자혈청AGEs농도현저승고，AGEs시반영체내양화응격수평교호적혈청학지표，병차여병정적엄중정도정정상관，대병정전귀유일정예측개치。
Objective To examine the advanced glycation end products(AGEs)in patients with acute coronary syndrome(ACS) and discuss the relationship between oxidative stress with the development of atherosclerosis(AS), and explore their influences to prognosis of ACS.Methods Plasma collected in 72 acute myocardial infarction(AMI) patients、53 unstable angina pectoris(UA) patients and 27 non-CAD patients. AGEs levels detected by fluorescence spectroscopy. All ACS patients were followed up for six months.Results Compared with normal group (without CAD), significantly higher plasma AGEs were found in AMI &UA patients(P<0.05), and lower plasma AGEs were better in the prognosis of ACS.Conclusion The higher levels of AGEs in ACS patients showed that AGEs may be as a good marker in ACS and regarded as a indication forthe prognosis of ACS.