CAJ | 학술논문

CO-029作为四跨膜蛋白超家族的重要成员之一，已有研究显示其在促进肿瘤侵袭与转移中的重要作用，但其具体机制仍知之甚少。研究明确其作用机制，有揭示肿瘤发生发展过程机制，作为预测肿瘤的进展及预后，进而开发新的肿瘤靶向治疗药物的潜在临床价值。
CO-029작위사과막단백초가족적중요성원지일，이유연구현시기재촉진종류침습여전이중적중요작용，단기구체궤제잉지지심소。연구명학기작용궤제，유게시종류발생발전과정궤제，작위예측종류적진전급예후，진이개발신적종류파향치료약물적잠재림상개치。
CO-029 belongs to the tetraspanins family, and has been revealed to play an important role in inva-sion and metastasis of carcinoma. However, how CO-029 promotes cancer invasion and metastasis is still poorly un-derstood. Its explicit mechanisms in the development of tumor probably indicates that CO-029 has great potential clin-ical value in predicting the progression and the prognosis of cancer, and may be a potent molecular therapeutic target for cancer.