CAJ | 학술논문

目的：探讨帕金森病轻度认知障碍的相关因素及其对生活质量的影响。方法选择82例帕金森病(PD)患者(未合并帕金森痴呆)，根据是否合并轻度认知功能障碍(MCI)分为PD-MCI组与PD-NCI组，比较两组患者的临床资料，并采用Webster症状评分评价病情程度，采用Zung抑郁自评量表（SDS）评价抑郁情况，采用帕金森病生活质量问卷(PDQL-39)评估PD患者的生活质量。结果82例PD患者中PD-MCI发生率为54.88%(45/82)；单因素分析显示，PD患者病程长、受教育年限短、体力劳动比例高、SDS评分高、病情程度重、血尿酸水平低者更容易产生轻度认知损害(P<0.05)；PD-MCI组患者PDQL-39评分为(130.6±12.8)分，明显低于PD-NCI组的(144.4±15.5)分，差异有统计学意义(P<0.05)。结论 PD-MCI的发生与病程长、受教育年限短、体力劳动比例高、抑郁、病情程度重、血尿酸水平低等因素有关，且PD-MCI可对PD患者生活质量造成明显影响。
목적：탐토파금삼병경도인지장애적상관인소급기대생활질량적영향。방법선택82례파금삼병(PD)환자(미합병파금삼치태)，근거시부합병경도인지공능장애(MCI)분위PD-MCI조여PD-NCI조，비교량조환자적림상자료，병채용Webster증상평분평개병정정도，채용Zung억욱자평량표（SDS）평개억욱정황，채용파금삼병생활질량문권(PDQL-39)평고PD환자적생활질량。결과82례PD환자중PD-MCI발생솔위54.88%(45/82)；단인소분석현시，PD환자병정장、수교육년한단、체력노동비례고、SDS평분고、병정정도중、혈뇨산수평저자경용역산생경도인지손해(P<0.05)；PD-MCI조환자PDQL-39평분위(130.6±12.8)분，명현저우PD-NCI조적(144.4±15.5)분，차이유통계학의의(P<0.05)。결론 PD-MCI적발생여병정장、수교육년한단、체력노동비례고、억욱、병정정도중、혈뇨산수평저등인소유관，차PD-MCI가대PD환자생활질량조성명현영향。
Objective To investigate the relevant factors of Parkinson's disease with mild cognitive impair-ment and its impact on quality of life. Methods Eighty-two patients with Parkinson's disease (PD) (without Parkin-son dementia) were divided into PD-MCI group and PD-NCI group according to whether with mild cognitive impair-ment (MCI). The clinical data and Webster symptom score, Zung Self-Rating Depression Scale and Parkinson's dis-ease using the Quality of Life Questionnaire (PDQL-39) were compared in the two groups. Results In the 82 PD pa-tients, the rate of PD-MCI was 54.88%(45/82). Univariate analysis showed that, PD patients with longer duration, se-verity of heavy short years of education, high proportion of manual labor, high SDS score, lower blood uric acid levels were more likely with mild cognitive impairment (P<0.05). The PDQL-39 score in PD-MCI group was (130.6±12.8), which was significantly lower than that in the PD-NCI group, (144.4±15.5), P<0.05. Conclusion The factors of lon-ger duration, short education years, high proportion of manual labor, depression, severity weight, lower blood uric acid level are associated with PD-MCI. PD-MCI could cause significant impact on the quality of life of PD patients.