CAJ | 학술논문

目的：探讨低频及高频重复经颅磁刺激（rTMS）对脑卒中后抑郁（PSD）的治疗作用。方法将111例PSD患者随机分为低频组37例（接受1 Hz低频rTMS治疗）、高频组37例（接受10 Hz高频rTMS治疗）和对照组37例（接受假刺激治疗），每周5次，共治疗4周。于治疗前、治疗第2周末及治疗第4周末分别采用汉密尔顿抑郁量表（HAMD）对3组患者评分。结果 rTMS治疗前，3组HAMD评分差异无统计学意义；治疗后第2、4周末，低频组、高频组 HAMD评分明显低于对照组，特别是高频组；治疗后第2周末，高频组HAMD评分下降幅度较低频组明显。结论低频与高频rTMS治疗PSD安全有效，高频rTMS治疗起效更快。
목적：탐토저빈급고빈중복경로자자격（rTMS）대뇌졸중후억욱（PSD）적치료작용。방법장111례PSD환자수궤분위저빈조37례（접수1 Hz저빈rTMS치료）、고빈조37례（접수10 Hz고빈rTMS치료）화대조조37례（접수가자격치료），매주5차，공치료4주。우치료전、치료제2주말급치료제4주말분별채용한밀이돈억욱량표（HAMD）대3조환자평분。결과 rTMS치료전，3조HAMD평분차이무통계학의의；치료후제2、4주말，저빈조、고빈조 HAMD평분명현저우대조조，특별시고빈조；치료후제2주말，고빈조HAMD평분하강폭도교저빈조명현。결론저빈여고빈rTMS치료PSD안전유효，고빈rTMS치료기효경쾌。
Objective To investigate the curative effect of low-or high-frequency repetitive transcranial magnetic stimula-tion (rTMS) on patients with depression after stroke (PSD).Methods One hundred and eleven patients with PSD were ran-domly divided into low-frequency group (n=37 ,treated with 1 Hz low frequency rTMS) ,high-frequency group (n=37 ,trea-ted with 10 Hz high-frequency rTMS) and control group (n=37 ,treated by sham stimulation). Three groups were treated by five times per week and a total of 4 weeks treatment. The Hamilton Rating Scale for Depression (HAMD) was used to evaluate the condition of three groups before treatment ,2nd and 4th week after treatment.Results The HAMD scores among three groups had no significant difference before rTMS treatment ;the HAMD score of low-and high-frequency groups were lower than that of control group ,especially in the high-frequency group 2nd and 4th week after treatment ;the descend range of HAMD score in the high-frequency group was larger than that in the low-frequency group 2nd week after treatment.Conclusion Low-and high-frequency rTMS has better curative effect on patients with PSD ,especially in the high-frequency rTMS thera-py.