CAJ | 학술논문

目的：探讨纳洛酮用于新生儿重度窒息治疗时对患儿神经功能及大脑血供的影响。方法86例重度窒息新生儿随机分为观察组（n＝43）与对照组（n＝43），对照组仅给予常规治疗，观察组在对照组基础上加用纳洛酮治疗，对比2组患儿神经功能及大脑血供变化。结果观察组有效率显著高于对照组（P＜0.01）；治疗后2组患儿NBNA评分均显著增高（P＜0.01），且观察组治疗后＞35分患儿显著多于对照组（P＜0.01），2组患儿NSE及S100蛋白也较治疗前明显降低（P＜0.01），且治疗后观察组显著低于对照组（P＜0.01）；2组患儿治疗后大脑中动脉 Vs、Vd均显著增加（P＜0.01），且治疗后观察组显著高于对照组（P＜0.01），2组血管阻力指数均显著降低（P＜0.01），且治疗后观察组显著低于对照组（P＜0.01）。结论纳洛酮用于新生儿重度窒息能够有效改善患儿神经功能状态及大脑血供，而脑血流灌注的增加将促进脑损伤及神经功能的恢复，疗效确切，值得推广。
목적：탐토납락동용우신생인중도질식치료시대환인신경공능급대뇌혈공적영향。방법86례중도질식신생인수궤분위관찰조（n＝43）여대조조（n＝43），대조조부급여상규치료，관찰조재대조조기출상가용납락동치료，대비2조환인신경공능급대뇌혈공변화。결과관찰조유효솔현저고우대조조（P＜0.01）；치료후2조환인NBNA평분균현저증고（P＜0.01），차관찰조치료후＞35분환인현저다우대조조（P＜0.01），2조환인NSE급S100단백야교치료전명현강저（P＜0.01），차치료후관찰조현저저우대조조（P＜0.01）；2조환인치료후대뇌중동맥 Vs、Vd균현저증가（P＜0.01），차치료후관찰조현저고우대조조（P＜0.01），2조혈관조력지수균현저강저（P＜0.01），차치료후관찰조현저저우대조조（P＜0.01）。결론납락동용우신생인중도질식능구유효개선환인신경공능상태급대뇌혈공，이뇌혈류관주적증가장촉진뇌손상급신경공능적회복，료효학절，치득추엄。
Objective To investigate the influence of naloxone on the neurological function and cerebral blood supply of ne-onate with severe asphyxia. Methods Eighty-six neonate with severe asphyxia were randomly divided into the observation group (n=43 ,treated by conventional therapy combined with naloxone ) and control group (n=43 ,treated by conventional therapy). The neurological function and cerebral blood supply of two groups were compared.Results The effective rate of ob-servation group was significantly higher than that of control group (P<0.01);the cases of NBNA score>35 ,Vs and Vd of middle cerebral artery in the observation group were significantly increased and higher than these in the control group (P<0.01);the NSE and S100 protein and IR in the observation group were significantly decreased and lower than these in the con-trol group (P<0.01).Conclusion Naloxone can effectively improve the neurological function and cerebral blood supply in neo-nate with severe asphyxia ,which is worthy of applicaiton.