CAJ | 학술논문

目的：观察阿托伐他汀对短暂性脑缺血发作（T IA ）患者转归的影响。方法130例T IA患者随机分为高剂量（40 mg/d）阿托伐他汀治疗组（H组）和低剂量（10 mg/d）阿托伐他汀治疗组（L组）各65例，2组患者均给予相同的基础治疗。观察2组患者住院及随诊1 a期间T IA复发及形成梗死、新发冠脉事件、脑出血及死亡情况，并比较2组1 a点LDL水平。结果住院期间和随访期间，H组TIA复发率、梗死及新发冠脉事件发生率及LDL水平明显低于L组。结论高剂量（40 mg/d）阿托伐他汀能显著改善短暂性脑缺血患者的发作，值得临床推广。
목적：관찰아탁벌타정대단잠성뇌결혈발작（T IA ）환자전귀적영향。방법130례T IA환자수궤분위고제량（40 mg/d）아탁벌타정치료조（H조）화저제량（10 mg/d）아탁벌타정치료조（L조）각65례，2조환자균급여상동적기출치료。관찰2조환자주원급수진1 a기간T IA복발급형성경사、신발관맥사건、뇌출혈급사망정황，병비교2조1 a점LDL수평。결과주원기간화수방기간，H조TIA복발솔、경사급신발관맥사건발생솔급LDL수평명현저우L조。결론고제량（40 mg/d）아탁벌타정능현저개선단잠성뇌결혈환자적발작，치득림상추엄。
Objective To investigate the effect of atorvastatin on patients with transient ischemic attack (TIA). Methods One hundred and thirty patients with TIA were randomly divided into the high dose of atorvastatin (40 mg/d ,H group) and low dose of atorvastatin (40 mg/d ,L group). The recurrence and forming cerebral infarction ,new coronary events ,cerebral hemorrhage and death ,and LDL level of two groups were compared.Results The TIA recurrence rate ,cerebral infarction and less new coronary events and LDL level of H group were lower than these of L group. Conclusion The high dose of atorvasta-tin (40 mg/d) can significantly improve the attack of patients with transient cerebral ischemia ,which is worthy of application.