CAJ | 학술논문

目的：探讨卵巢原发性类癌的临床病理特征。方法报道2例卵巢原发性类癌，并结合相关文献进行临床病理分析。结果病例1为岛状型类癌，肿瘤细胞呈圆形或多角形，排列成岛状或假菊团状，行单侧附件切除术；病例2为梁状型类癌，肿瘤细胞呈柱状，小梁由单至多层瘤细胞构成，瘤细胞核长轴与小梁走向垂直，其临床上有便秘的症状，术后缓解，行全子宫加双附件切除术。术后随访45个月和63个月均未见复发证据。免疫组化肿瘤细胞均呈不同程度的Syn(+)、CK(+)；α-inhibin、CD99、TTF-1、ER、PR均(-)；Ki-67增殖指数<1%。结论卵巢原发性类癌临床罕见，诊断需和颗粒细胞瘤、支持细胞瘤等鉴别，并排除转移性类癌。作为一种低度恶性肿瘤，卵巢类癌多数预后良好。
목적：탐토란소원발성유암적림상병리특정。방법보도2례란소원발성유암，병결합상관문헌진행림상병리분석。결과병례1위도상형유암，종류세포정원형혹다각형，배렬성도상혹가국단상，행단측부건절제술；병례2위량상형유암，종류세포정주상，소량유단지다층류세포구성，류세포핵장축여소량주향수직，기림상상유편비적증상，술후완해，행전자궁가쌍부건절제술。술후수방45개월화63개월균미견복발증거。면역조화종류세포균정불동정도적Syn(+)、CK(+)；α-inhibin、CD99、TTF-1、ER、PR균(-)；Ki-67증식지수<1%。결론란소원발성유암림상한견，진단수화과립세포류、지지세포류등감별，병배제전이성유암。작위일충저도악성종류，란소유암다수예후량호。
Objective To investigate the clinicopathological features of primary ovarian carcinoid. Methods Two primary ovarian carcinoid cases from the clinicpathology perspective were reported and ana-lyzed, in combination with relevant literature reviews. Results Case 1 was isular carcinoid. The tumor cells were round or polygonal, and arranged in a shape of island or pseudorosettes. And unilateral adnexectomy was performed. Case 2 was trabecular carcinoid. The tumor cells were columnar, and the trabecula was made up of monolayer or multi-layer tumor cells. The long axes of the tumor cell nucleus were perpendicular to the trend of the trabecula. The consti-pation symptom was relieved after surgery of total hysterectomy and bilateral adnexectomy. There was no evidence of relapse after the respective follow-up of 45 months and 63 months. Immunohistochemical tumor cells showed differ-ent level of positive to Syn and CK in bothcases, while negative toα-inhibin, CD99, TTF-1, ER, and PR, with Ki-67 proliferation index<1%. Conclusion Primary ovarian carcinoid is relatively rare, therefore its diagnosing should be differentiated from that of the granulosa cell tumor, Sertoli cell tumor and metastatic carcinoid. Ovarian carcinoid is a low-grade malignant tumor with favorable prognosis.