CAJ | 학술논문

目的：观察薄芝糖肽注射液、玉屏风颗粒联合盐酸左西替利嗪片治疗顽固性湿疹的临床疗效及安全性。方法将入选的104例患者按就诊顺序随机分为两组，各52例。全部予盐酸左西替利嗪分散片5 mg口服(1次/d)，治疗组还予薄芝糖肽注射液2 ml肌注(隔天1次)和玉屏风颗粒5 g口服(3次/d)，两组患者均连续用药4周。观察治疗第1、2和4周时的临床疗效，随访半年观察复发情况。结果治疗组有1例因为用药第3天出现头痛而中止治疗，实际有效病例51例，对照组有效病例52例。治疗第1、2和4周时治疗组症状体征总积分分别为(8.93±2.43)分、(3.38±1.37)分和(1.33±0.58)分，对照组为(9.16±2.62)分、(6.61±4.11)分和(3.45±1.27)分。治疗组有效率分别为50.98%、82.35%和96.08%，对照组分别为40.38%、71.15%和80.77%；结果显示治疗1、2、4周后，治疗组症状体征总积分和有效率均明显优于对照组，差异均有统计学意义(P<0.05)。随访半年，治疗组复发率(20.41%)明显低于对照组(70.45%)(P<0.05)。治疗组不良反应发生率（(1.96%)和对照组(0)比较，差异无统计学意义(P>0.05)。结论薄芝糖肽注射液、玉屏风颗粒联合抗组胺药治疗难治性湿疹的疗效满意，停药后复发率低。
목적：관찰박지당태주사액、옥병풍과립연합염산좌서체리진편치료완고성습진적림상료효급안전성。방법장입선적104례환자안취진순서수궤분위량조，각52례。전부여염산좌서체리진분산편5 mg구복(1차/d)，치료조환여박지당태주사액2 ml기주(격천1차)화옥병풍과립5 g구복(3차/d)，량조환자균련속용약4주。관찰치료제1、2화4주시적림상료효，수방반년관찰복발정황。결과치료조유1례인위용약제3천출현두통이중지치료，실제유효병례51례，대조조유효병례52례。치료제1、2화4주시치료조증상체정총적분분별위(8.93±2.43)분、(3.38±1.37)분화(1.33±0.58)분，대조조위(9.16±2.62)분、(6.61±4.11)분화(3.45±1.27)분。치료조유효솔분별위50.98%、82.35%화96.08%，대조조분별위40.38%、71.15%화80.77%；결과현시치료1、2、4주후，치료조증상체정총적분화유효솔균명현우우대조조，차이균유통계학의의(P<0.05)。수방반년，치료조복발솔(20.41%)명현저우대조조(70.45%)(P<0.05)。치료조불량반응발생솔（(1.96%)화대조조(0)비교，차이무통계학의의(P>0.05)。결론박지당태주사액、옥병풍과립연합항조알약치료난치성습진적료효만의，정약후복발솔저。
Objective To investigate the clinical effect of BozhiGlycopeptideinjection combined with Yup-ingfeng granule and levocetirizine tablets in the treatment of refractory eczema. Methods A total of 104 patients were randomly divided into two groups, each of 52 cases. All the patients were treated with levocetirizine tablets 5 mg once daily. The treatment group was given intramuscular injection of BozhiGlycopeptideinjection 2 ml every two days and Yupingfeng granule 5 g three times a day. The two groups patients were treated for 4 weeks. The clinical curative effect of 1st, 2nd and 4th week was observed, and both groups were followed-up for six months to observe the recur-rence. Results A patient in the treatment group discontinued the treatment for headache in the third day. Thus the treatment group enrolled 51 cases and the control group included 52 cases. The total scores of symptoms and signs were (8.93±2.43), (3.38±1.37), (1.33±0.58) at the 1st, 2nd and 4th week after treatment in the treatment group, and (9.16± 2.62), (6.61 ± 4.11), (3.45 ± 1.27) in the control group. The effective rates were 50.98%, 82.35%, 96.08%in the treat-ment group and 40.38%, 71.15%, 80.77%in the control group at the 1st, 2nd and 4th week after treatment. The results showed that the symptoms and signs total score and the effective rate in the treatment group were significantly better than those in the control group (P<0.05). After six months of follow-up, the recurrence rate was 20.14%in treatment group and 70.45%in the control group, with statistically significant difference (P<0.05). The incidence of adverse reaction was 1.96% in the treatment group and 0 in the control group, with no statistically significant difference (P>0.05). Conclusion The effect of BozhiGlycopeptideInjection combined with Yupingfeng granule and antihista-mine is satisfactory for the treatment of refractory eczema, with a low recurrence rate.