CAJ | 학술논문

目的：研究血浆同型半胱氨酸(Hcy)脐血流彩色多普勒超声检测与子痫前期(PE)患者病情轻重程度的相关性。方法测定70例正常晚期妊娠(对照组)、72例轻度PE(轻度PE组)、66例重度PE(重度PE组)患者的血浆Hcy水平及脐动脉血流参数水平。结果对照组、PE轻度组、PE重度组的Hcy水平分别为(8.950±0.585)μmol/L、(11.116±0.615)μmol/L和(14.648±0.620)μmol/L,两两比较均有显著差异(P<0.05)。重度PE组脐动脉血流参数S/D值显著高于对照组、轻度PE组(P<0.05),而对照组、轻度PE组则无显著差异(P>0.05)；轻度PE组、重度PE组中阻力指数(RI)、搏动指数(PI)明显高于对照组,而轻度PE组、重度PE组则无显著差异(P>0.05)。 Hcy与S/D呈正相关(r=0.684,=0.001)；Hcy与RI呈正相关(r=0.524,=0.006),Hcy与PI呈正相关性(r=0.203,=0.03)。 Hcy与PE病情程度呈正相关(r=0.450,P<0.05),S/D与PE病情严重程度呈正相关(r=0.316,=0.002)；RI、PI与PE病情轻重无相关性(r=0.024,=0.726)。结论随着PE患者的病情加重,Hcy、S/D水平呈升高趋势,降低Hcy、监测S/D可能成为诊治子痫前期提一种新的思路。
목적：연구혈장동형반광안산(Hcy)제혈류채색다보륵초성검측여자간전기(PE)환자병정경중정도적상관성。방법측정70례정상만기임신(대조조)、72례경도PE(경도PE조)、66례중도PE(중도PE조)환자적혈장Hcy수평급제동맥혈류삼수수평。결과대조조、PE경도조、PE중도조적Hcy수평분별위(8.950±0.585)μmol/L、(11.116±0.615)μmol/L화(14.648±0.620)μmol/L,량량비교균유현저차이(P<0.05)。중도PE조제동맥혈류삼수S/D치현저고우대조조、경도PE조(P<0.05),이대조조、경도PE조칙무현저차이(P>0.05)；경도PE조、중도PE조중조력지수(RI)、박동지수(PI)명현고우대조조,이경도PE조、중도PE조칙무현저차이(P>0.05)。 Hcy여S/D정정상관(r=0.684,=0.001)；Hcy여RI정정상관(r=0.524,=0.006),Hcy여PI정정상관성(r=0.203,=0.03)。 Hcy여PE병정정도정정상관(r=0.450,P<0.05),S/D여PE병정엄중정도정정상관(r=0.316,=0.002)；RI、PI여PE병정경중무상관성(r=0.024,=0.726)。결론수착PE환자적병정가중,Hcy、S/D수평정승고추세,강저Hcy、감측S/D가능성위진치자간전기제일충신적사로。
Objective To analyze the relationship between the levels of plasma total homocysteine (Hcy)and umbilical arterial with color doppler ultrasound with the severity of preeclampsia.Methods A total of 31 cases of the third trimester of normal pregnancy,33 cases of mild preeclampsia,and 36 cases of severe preeclampsia were selected,Then detect plasma Hcy levels and umbilical arterial with color doppler ultrasound. Results Hcy levels were statistical y significant dif erence among the normal control group,mild preeclampsia group,and severe preeclampsia group ( <0.05);umbilical artery blood flow parameter S/D values in Severe PE groupwas significantly higher in mild PE group( <0.05),while the control group,mild PE group had no significant dif erence( >0.05);resistance index(RI), pulsatility index(PI)in mild PE group and severe PE group were significantly higher,while the mild PE,severe PE group had no significant dif erence( >0.05).Hcy and S/D was positively correlated(r=0.684, =0.001);Hcy was positively cor elated with RI( =0.524,P=0.006),Hcy and PI was positive cor elation( =0.203, =0.03).Hcy and the severity of PE was positively cor elated( =0.450, <0.05),S/D and the severity of PE was positively cor elated(=0.316, =0.002);RI,PI and the severity of PE was no correlation( =0.024, =0.726).Conclusion The levels of Hcy and S/D were related to the severity of Preeclampsia.To Reduce Hcy,and monitor S/D were new ways for the diagnosis and treatment of pre-eclampsia.