CAJ | 학술논문

目的：探讨肿瘤出芽在胃肠道恶性肿瘤的临床病理诊断中的价值。方法光镜下观察262例胃癌和肠癌标本的肿瘤出芽情况，分析肿瘤出芽与胃肠道恶性肿瘤的临床病理指标和早期复发之间的关系。结果262例胃癌和肠癌中共有139例发生了肿瘤出芽（53.05%）。有肿瘤出芽组患者的淋巴结转移、淋巴管浸润和早期复发更多见（P<0.01），有肿瘤出芽组的肿瘤TNM分期明显高于无肿瘤出芽组（P<0.01）；但两组患者的肿瘤发生部位、分化程度和浸润深度无明显差异（P>0.05）。结论肿瘤出芽与反映胃肠道恶性肿瘤侵袭性的临床病理指标密切相关，有肿瘤出芽者早期复发多见。
목적：탐토종류출아재위장도악성종류적림상병리진단중적개치。방법광경하관찰262례위암화장암표본적종류출아정황，분석종류출아여위장도악성종류적림상병리지표화조기복발지간적관계。결과262례위암화장암중공유139례발생료종류출아（53.05%）。유종류출아조환자적림파결전이、림파관침윤화조기복발경다견（P<0.01），유종류출아조적종류TNM분기명현고우무종류출아조（P<0.01）；단량조환자적종류발생부위、분화정도화침윤심도무명현차이（P>0.05）。결론종류출아여반영위장도악성종류침습성적림상병리지표밀절상관，유종류출아자조기복발다견。
Objective To explore the value of clinical pathological diagnosis of tumor budding in gastro-intestinal ma-lignant neoplasm. Methods Tumor budding was observed in 262 cases of gastric adenocarcinoma and intestinal adenocarci-noma under the light microscope. To analyze the relation between tumor budding and the clinical pathological markers ,early re-currence in gastro-intestinal malignant neoplasm. Results Tumor budding was found in 139 cases of gastric adenocarcinoma and intestinal adenocarcinoma (53.05%). Lymph node metastasis, lymphatic invasion and early recurrence were more frequently observed in patients with tumor budding (P<0.01). TNM stage was higher in tumor budding than in non-tumor budding(P<0.01). Tumor budding was not associated with tumor site,differentiation and depth of infiltration. Conclusion Tumor budding is significantly associated wih the clinical pathological markers of gastro-intestinal malignant neoplasm. Early recurrence is more frequent in gastro-intestinal malignant neoplasm with tumor budding.