CAJ | 학술논문

基质金属蛋白酶(MMPs)家族是细胞外蛋白水解酶,几乎可以降解所有细胞外的基质成份.普遍认为肿瘤细胞或周围基质中MMPs特异性高表达是肿瘤形成的一个重要原因,因此研究用人工合成的MMP抑制剂治疗肿瘤已成为研究领域的热点.遗憾的是在临床试验阶段该治疗方法并没有达到预期的效果.近年来通过对肿瘤初期、转移后的表达研究发现,MMPs在肿瘤发展的多个阶段起着抑制肿瘤生长的作用.
기질금속단백매(MMPs)가족시세포외단백수해매,궤호가이강해소유세포외적기질성빈.보편인위종류세포혹주위기질중MMPs특이성고표체시종류형성적일개중요원인,인차연구용인공합성적MMP억제제치료종류이성위연구영역적열점.유감적시재림상시험계단해치료방법병몰유체도예기적효과.근년래통과대종류초기、전이후적표체연구발현,MMPs재종류발전적다개계단기착억제종류생장적작용.
The matrix metalloproteinase (MMP) family of extracellular proteases is associated with cancer invasion and metastasis by their ability to degrade all components of the extracellular matrix (ECM).It is widely believed that overexpression of a specific MMP by tumor cells or the surrounding stroma plays important roles during the process of tumor metastasis.Multiple studies have examined the potential value of these enzymes as targets for cancer therapy.Small molecule inhibitors of MMPs were tested for their potential as anticancer agents.However,most clinical trials with MMP inhibitors have yielded negative results.Therefore,it is necessury to re-evaluate the role of these proteases in cancer.