CAJ | 학술논문

哺乳动物囊胚在植入前，需从透明带中孵化出来才具有侵入子宫内膜的能力。囊胚孵化失败将引起女性不孕。囊胚孵化是一个受多因素精确调控的复杂过程，目前已发现的参与囊胚孵化的调控分子和信号通路，包括蛋白酶、环氧合酶-2、p38丝裂原活化蛋白激酶、激活素A和Wnt信号通路等。该文综述了有关因素对囊胚孵化的调控机制以及目前常用的囊胚辅助孵化的方法，为进一步阐明囊胚的孵化机制，为临床上对由于囊胚孵化失败引起女性不孕的治疗提供理论基础。
포유동물낭배재식입전，수종투명대중부화출래재구유침입자궁내막적능력。낭배부화실패장인기녀성불잉。낭배부화시일개수다인소정학조공적복잡과정，목전이발현적삼여낭배부화적조공분자화신호통로，포괄단백매、배양합매-2、p38사렬원활화단백격매、격활소A화Wnt신호통로등。해문종술료유관인소대낭배부화적조공궤제이급목전상용적낭배보조부화적방법，위진일보천명낭배적부화궤제，위림상상대유우낭배부화실패인기녀성불잉적치료제공이론기출。
Prior to implantation, the blastocyst has to hatch out of its zona pellucida to invade the endometrium .In mammals including humans , failure of blastocyst hatching leads to infertility .Blastocyst hatching is believed to be regulated by a variety of autocrine and paracrine molecules such as proteases , cyclooxygenase-2, p38 mitogen-activated protein ki-nase, activin A and Wnt signal pathway .This article reviews the mechanisms of the key molecular regulators involved in mammalian blastocyst hatching and hatching-assisting methods , which can help clarify the mechanism of blastocyst hatching and the treatment of infertility due to failure in blastocyst hatching .