CAJ | 학술논문

【目的】了解湖南省浏阳市地区人乳头瘤病毒（H PV ）感染的分布特点，为子宫颈癌的防治提供相关依据。【方法】采用导流杂交反斑点印迹（Reverse dot blo ，t RDB）快速基因分型监测技术对2009年6月至2012年6月在湖南省浏阳市人民医院就诊的11445例女性患者进行21种HPV基因亚型的检测。【结果】11445例检测中总的感染率为38．8％，其中高危感染率为35．9％，低危感染率为2．9％，共检测到19种基因型，其中以52型感染率最高，其他常见型分别为：16、58、CP8304、53、68、6、11型，其中45及43型未检测出。 HPV高危感染率各年龄组中≤30岁组和＞50岁组明显高于其他两组（31～50岁年龄段）（ P ＜0．05）。高危 HPV感染者薄层液基细胞学检测（TCT）异常行宫颈活检，其中＞50岁者宫颈癌检出率高于＜50岁者，但＞50岁者宫颈上皮内瘤变（CIN）Ⅰ检出率低于＜50岁者，＞40岁者CIN Ⅱ检出率高于＜40岁者，且＞50岁者CINⅡ检出率高于41～50岁者。多重感染率＞50岁组高于其他三组（＜50岁年龄段）。高危HPV多重感染中年龄＞40岁者CIN Ⅲ检出率高于＜40岁者。【结论】湖南省浏阳市地区 HPV感染的基因分型符合亚洲人群分布规律，但有地区特点。且高危感染者中宫颈活检阳性率有随年龄增长而增高的趋势，＞50岁感染高危H PV者要加强随访，多重感染且＞40岁者要注意加强随访。
【목적】료해호남성류양시지구인유두류병독（H PV ）감염적분포특점，위자궁경암적방치제공상관의거。【방법】채용도류잡교반반점인적（Reverse dot blo ，t RDB）쾌속기인분형감측기술대2009년6월지2012년6월재호남성류양시인민의원취진적11445례녀성환자진행21충HPV기인아형적검측。【결과】11445례검측중총적감염솔위38．8％，기중고위감염솔위35．9％，저위감염솔위2．9％，공검측도19충기인형，기중이52형감염솔최고，기타상견형분별위：16、58、CP8304、53、68、6、11형，기중45급43형미검측출。 HPV고위감염솔각년령조중≤30세조화＞50세조명현고우기타량조（31～50세년령단）（ P ＜0．05）。고위 HPV감염자박층액기세포학검측（TCT）이상행궁경활검，기중＞50세자궁경암검출솔고우＜50세자，단＞50세자궁경상피내류변（CIN）Ⅰ검출솔저우＜50세자，＞40세자CIN Ⅱ검출솔고우＜40세자，차＞50세자CINⅡ검출솔고우41～50세자。다중감염솔＞50세조고우기타삼조（＜50세년령단）。고위HPV다중감염중년령＞40세자CIN Ⅲ검출솔고우＜40세자。【결론】호남성류양시지구 HPV감염적기인분형부합아주인군분포규률，단유지구특점。차고위감염자중궁경활검양성솔유수년령증장이증고적추세，＞50세감염고위H PV자요가강수방，다중감염차＞40세자요주의가강수방。
[Objective] To understand the distribution of human papillomavirus (HPV ) infection in Liuyang city of Hunan province so as to provide the relevant evidence for cervical cancer .[Methods] Rapid genotyping method with reverse dot blot(RDB) was used to detect 21 HPV sub‐genotypes of 11 ,445 female patients in Liuy‐ang city of Hunan province from June 2009 to June 2012 .[Results]Among 11 ,445 patients ,the overall infection rate was 38 .8% ,and the high‐risk infection rate was 35 .9% ,and the low‐risk infection rate was 2 .9% .The 19 genotypes were detected . The infection rate of HPV52 was the highest . The other common genotypes were HPV16 ,58 ,CP8304 ,53 ,68 ,6 and 11 .HPV45 and HPV43 genotypes were not detected .High‐risk infection rate in the age groups with ≤30 years old and >50 years old was higher than those in other two groups (between 31 and 51 years old)( P <0 .05) .High‐risk HPV infection patients with abnormal TCT received cervical biopsy . The detection rate of cervical cancer in patients with > 50 years old was higher than that in patients with < 50 years old ,but the detection rate of intraepithelia neoplasia grade Ⅰ (CINⅠ ) in patients with >50 years old was lower than that in patients with <50 years old ,and the detection rate of intraepithelia neoplasia grade Ⅱ(CINⅡ) in patients with >40 years old was higher than that in patients with <40 years old ,and the detection rate of CINII in patients with >50 years old was higher than that in patients with 41~50 years old .The multi‐infection rate in age group with >50 years old was higher than those in other 3 age groups(<50 years old ) .The detection rate of intraepithelia neoplasia grade Ⅲ(CINⅢ) in patients with >40 years old was higher than that in patients with <40 years old .[Conclusion]The genotyping of HPV infection in Liuyang city of Hunan province is consistent with the distribution regularity of Asian population ,but has some regional characteristics .The positive rate of cervical bi‐opsy in patients with high‐risk infection trends to increase with the age .The high‐risk infection patients with >50 years old and the multi‐infection patients with >40 years old should be paid attention to strengthen the follow up .